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Maternal and fetal cardiovascular effects and placental transfer of the oxytocin antagonist atosiban in late-gestation pregnant sheep
- Source :
- American Journal of Obstetrics and Gynecology. 169:897-902
- Publication Year :
- 1993
- Publisher :
- Elsevier BV, 1993.
-
Abstract
- Objectives: Atosiban is a synthetic oxytocin antagonist that is currently undergoing dose-ranging clinical trials. To date, no data are available on the cardiovascular effects of combined oxytocin and vasopressin blockade during late pregnancy. Our aims were (1) to determine the effects of atosiban infusion on the maternal and fetal cardiovascular system and on uterine blood flow and (2) to determine the maternal pharmacokinetics and the rate of placental transfer of atosiban. Study Design: Five chronically catheterized pregnant sheep were treated with a 2-hour infusion of atosiban (300 μg · min −1 ) at 116 to 126 days' gestation. Maternal and fetal blood pressure and heart rate and uterine blood flow were measured before and during the infusion. Maternal and fetal arterial blood samples were obtained throughout the experiment for measurement of plasma atosiban levels and blood gas values. Results: No significant change in maternal cardiovascular parameters or uterine blood flow were observed. Similarly, no changes in fetal blood pressure and arterial blood gases were present during the infusion of the atosiban. Maternal plasma levels of atosiban reached a maximum of 585.2 ± 82.2 (ng/ml mean ± SD) at the end of the infusion and decreased biexponentially with a mean t ½α of 17 minutes and a mean t ½β of 2.2 hours. Fetal plasma levels of atosiban were at or below the detection limit. Conclusion: Atosiban does not significantly affect maternal or fetal cardiovascular parameters when it is administered for 2 hours in late-pregnant sheep. Although significant levels were measured in maternal blood, negligible transfer to the fetus occurred.
- Subjects :
- medicine.medical_specialty
Vasopressin
Placenta
Hemodynamics
Blood Pressure
Oxytocin
Cardiovascular System
Fetus
Vasotocin
Heart Rate
Pregnancy
Internal medicine
medicine
Animals
Maternal-Fetal Exchange
Sheep
business.industry
Uterus
Obstetrics and Gynecology
Biological Transport
Atosiban
Arteries
Blood flow
Carbon Dioxide
Hydrogen-Ion Concentration
Fetal Blood
Oxygen
Blood pressure
Endocrinology
Regional Blood Flow
Pregnancy, Animal
Gestation
Arterial blood
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 00029378
- Volume :
- 169
- Database :
- OpenAIRE
- Journal :
- American Journal of Obstetrics and Gynecology
- Accession number :
- edsair.doi.dedup.....094f866e44bb5f2bdfe3e605b9e8ea25