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An elevated preoperative serum carbohydrate antigen 19-9 level is a significant predictor for peritoneal dissemination and poor survival in colorectal cancer
- Source :
- Colorectal Disease. 17:417-425
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Aim Many studies support the role of carcinoembryonic antigen (CEA) as a strong indicator of the status of colorectal cancer patients, but evidence for carbohydrate antigen 19-9 (CA19-9) is poor. For this reason the study aimed to evaluate the prognostic value of preoperative serum CA19-9 levels in colorectal cancer patients. Method In all, 1190 colorectal cancer patients were included in this study, of whom 955 underwent a potentially curative resection. These were analysed for recurrence and survival. The 255 patients with Stage IV disease were analysed for metastatic status. Results Patients with an elevated preoperative CEA with Stage II and III disease showed a significantly poorer survival than those with normal levels. In contrast patients with elevated preoperative CA19-9 levels were associated with a significantly poorer survival irrespective of disease stage. Of the 255 patients with Stage IV disease, 92 (39.1%) had peritoneal dissemination at laparotomy observed more frequently in patients with an elevated CA19-9 (47.9%). Of the 955 patients having a curative resection, 18 (1.9%) developed peritoneal dissemination. In multivariate analysis, an elevated preoperative CA19-9 level was a significant risk factor for postoperative peritoneal recurrence. Conclusion After curative surgery for colorectal cancer the preoperative CA19-9 level is a strong prognostic indicator of higher risk of peritoneal dissemination.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Multivariate analysis
CA-19-9 Antigen
endocrine system diseases
Colorectal cancer
medicine.medical_treatment
Disease
Young Adult
Carcinoembryonic antigen
Laparotomy
Internal medicine
Biomarkers, Tumor
medicine
Humans
Stage (cooking)
Peritoneal Neoplasms
Aged
Retrospective Studies
Aged, 80 and over
biology
business.industry
Carcinoma
Gastroenterology
Middle Aged
Prognosis
medicine.disease
digestive system diseases
Carcinoembryonic Antigen
Logistic Models
Multivariate Analysis
Preoperative Period
biology.protein
Female
CA19-9
Neoplasm Recurrence, Local
Colorectal Neoplasms
business
Carbohydrate antigen
Subjects
Details
- ISSN :
- 14628910
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Colorectal Disease
- Accession number :
- edsair.doi.dedup.....0963ac0029855e0ea333a9f820bca56b