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Relative and absolute contributions of postprandial and fasting plasma glucose to daytime hyperglycaemia and HbA(1c) in subjects with Type 2 diabetes
- Source :
- Diabetic medicine : a journal of the British Diabetic Association. 26(10)
- Publication Year :
- 2009
-
Abstract
- To determine the relative and absolute contributions of postprandial glucose (PPG) and fasting or preprandial plasma glucose (FPG) to daytime hyperglycaemia and HbA(1c) respectively, in persons with type 2 diabetes (T2DM).Subjects (n = 52; 37 men) had 12hr plasma glucose (PG) profiles determined in response to three serial identical test meals. PPG exposure was calculated for each meal. Excess hyperglycaemia was calculated above a PG concentration of 5.5 mmol/l. Fasting hyperglycaemia was the difference between excess hyperglycaemia and PPG exposure. Subjects were divided into three groups according to HbA(1c)-(Gp1:7.3%;Gp2:7.3%-8.0%;Gp3:8.0%) and the relative contribution of PPG exposure and fasting hyperglycaemia to excess hyperglycaemia calculated for each meal. The absolute contribution of PPG and fasting hyperglycaemia to excess HbA(1c) (mean HbA(1c)-5.1%) was also calculated.The relative contributions of PPG exposure to excess hyperglycaemia for the three groups were: 58.3%, 54.3% and 35.4% (P = 0.483-Group 1 vs. Group 2; P = 0.002-Group 2 vs. Group 3) for meal 1; 69.8%, 54.7% and 23.7% (P = 0.163-Group 1 vs. Group 2; P = 0.005-Group 2 vs. Group 3) for meal 2; 85.8%, 70.2% and 48.6% (P = 0.153-Group 1 vs. Group 2; P = 0.046-Group 2 vs. Group 3) for meal 3. Absolute contributions of PPG to excess HbA(1c) in the three groups were 1.4%, 1.6% and 1.3% (P = NS).The relative contribution of postprandial glucose to excess hyperglycaemia decreases as glycaemic control deteriorates, being dominant with HbA(1c)/= 7.3%, irrespective of the timing of the meal during the day. However, the absolute contribution of postprandial glucose to excess HbA(1c) does not differ significantly ( approximately 1.5%) with varying glycaemic control.
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Type 2 diabetes
Endocrinology
Diabetes mellitus
Internal medicine
Internal Medicine
medicine
Fasting hyperglycaemia
Humans
Aged
Aged, 80 and over
Glycated Hemoglobin
Plasma glucose
Meal
business.industry
digestive, oral, and skin physiology
nutritional and metabolic diseases
Nutritional status
Fasting
Middle Aged
medicine.disease
Postprandial Period
Obesity
Postprandial
Diabetes Mellitus, Type 2
Hyperglycemia
Female
business
Subjects
Details
- ISSN :
- 14645491
- Volume :
- 26
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Diabetic medicine : a journal of the British Diabetic Association
- Accession number :
- edsair.doi.dedup.....0975cc8199742bb72437697fc95329d9