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Force-dependent elasticity of nucleic acids
- Source :
- Nanoscale. 15:6738-6744
- Publication Year :
- 2023
- Publisher :
- Royal Society of Chemistry (RSC), 2023.
-
Abstract
- The functioning of double-stranded (ds) nucleic acids (NAs) in cellular processes is strongly mediated by their elastic response. These processes involve proteins that interact with dsDNA or dsRNA and distort their structures. The perturbation of the elasticity of NAs arising from these deformations is not properly considered by most theoretical frameworks. In this work, we introduce a novel method to assess the impact of mechanical stress on the elastic response of dsDNA and dsRNA through the analysis of the fluctuations of the double helix. Application of this approach to atomistic simulations reveals qualitative differences in the force dependence of the mechanical properties of dsDNA with respect to those of dsRNA, which we relate to structural features of these molecules by means of physically-sound minimalistic models.<br />Comment: 6 pages, 2 figures
- Subjects :
- Chemical Physics (physics.chem-ph)
Optical Tweezers
Física
FOS: Physical sciences
Biomolecules (q-bio.BM)
DNA
Condensed Matter - Soft Condensed Matter
Quantitative Biology - Biomolecules
Biological Physics (physics.bio-ph)
Physics - Chemical Physics
FOS: Biological sciences
Soft Condensed Matter (cond-mat.soft)
Single Molecule
General Materials Science
Physics - Biological Physics
Subjects
Details
- ISSN :
- 20403372 and 20403364
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Nanoscale
- Accession number :
- edsair.doi.dedup.....097fb37dc042efaf992d65f4da94a83d