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Low-grade endotoxemia, gut permeability and platelet activation in patients with impaired fasting glucose
- Source :
- Nutrition, Metabolism and Cardiovascular Diseases. 27:890-895
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Impaired fasting glucose (IFG) is associated with an increased risk of cardiovascular disease but the underlying mechanisms are still unclear. Aim of the study was to investigate the interplay between platelet activation, lipopolysaccharides (LPS) and markers of oxidative stress in patients with IFG and control subjects.We performed a cross-sectional study including 35 patients with IFG and 35 control subjects who were well comparable for age, sex, body mass index and smoking history. Serum levels of LPS, zonulin (a marker of gut permeability), oxidized LDL and plasma levels of soluble P-selectin, were measured. Patients with IFG had significantly higher levels of sP-selectin, LPS, zonulin and oxLDL compared to control subjects. The IFG status (beta coefficient: 0.518, p 0.001), higher LPS (beta coefficient: 0.352, p = 0.001) and female sex (beta coefficient: 0.179, p = 0.042) were independently associated with higher sP-selectin; in addition, oxLDL was positively associated with sP-selectin (r = 0.530, p 0.001) and LPS (r = 0.529, p = 0.001). In IFG patients, we found a significant association between LPS and zonulin (r = 0.521, p = 0.001); this association was confirmed at multivariable analysis (beta coefficient: 0.512, p = 0.007).Our study provides evidence that patients with IFG have increased platelet activation, and suggests LPS as a potential trigger for in vivo platelet activation in this patient population.
- Subjects :
- Blood Glucose
Lipopolysaccharides
Male
0301 basic medicine
endocrine system diseases
P-selectin
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
030204 cardiovascular system & hematology
medicine.disease_cause
Oxidized low density lipoprotein
0302 clinical medicine
impaired blood glucose
Nutrition and Dietetics
Zonulin
Fasting
Middle Aged
Lipopolysaccharide
Platelet activation
Lipoproteins, LDL
Female
Cardiology and Cardiovascular Medicine
Cholera Toxin
medicine.medical_specialty
liposaccarides
platelet activation
Permeability
03 medical and health sciences
Internal medicine
Diabetes mellitus
Glucose Intolerance
medicine
Humans
Protein Precursors
Aged
Chi-Square Distribution
Haptoglobins
business.industry
Case-control study
nutritional and metabolic diseases
medicine.disease
Impaired fasting glucose
Endotoxemia
Gastrointestinal Tract
Oxidative Stress
Cross-Sectional Studies
030104 developmental biology
Endocrinology
Case-Control Studies
Multivariate Analysis
Linear Models
business
Body mass index
Biomarkers
Oxidative stress
Subjects
Details
- ISSN :
- 09394753
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Nutrition, Metabolism and Cardiovascular Diseases
- Accession number :
- edsair.doi.dedup.....098d4040b4a213d36b2625862e2dab23