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Evaluation of a ureteral catheter coating by means of a BioEncrustation in vitro model
- Source :
- International Journal of Pharmaceutics. 546:86-96
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Biomaterials for applications in the urinary tract are challenged with both biofilm formation and encrustation, two highly interconnected processes. While great effort has been achieved developing promising materials there is only a limited choice of sophisticated in vitro models that are available to analyse the performance of biomaterials prior to performing delicate and expensive in vivo studies. In this study we present a complex BioEncrustation model that imitates both the processes of multi-species biofilm formation and encrustation in vitro. The resulting crystalline biofilms are compared to the deposits found on explanted ureteral stent surfaces (in vivo situation) and to deposits formed in an experimental set up that does not contain bacteria (Encrustator®). Further focus of this study is dedicated to employing the developed BioEncrustation model to evaluate the effect multifunctional coatings impose on the processes of biofilm formation and encrustation under in vitro conditions. The investigated TANP coating combines unspecific and broad band specific antibacterial properties with a degrading polymer matrix that is intended to inhibit crystal formation. The coating was prepared on both polyurethane and silicone tubes and the subsequent results of the in vitro BioEncrustation analyses reveal a promising potential for employing the coating to render ureteral stent surfaces more biocompatible.
- Subjects :
- Male
0301 basic medicine
Silver
Materials science
030106 microbiology
030232 urology & nephrology
Metal Nanoparticles
Pharmaceutical Science
Biocompatible Materials
Urinary Catheters
Urine
engineering.material
Bacterial Physiological Phenomena
In vitro model
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Silicone
Polylactic Acid-Polyglycolic Acid Copolymer
Coating
In vivo
Humans
Lactic Acid
Aged
Aged, 80 and over
chemistry.chemical_classification
Bacteria
Biofilm
Polymer
Hydrogen-Ion Concentration
Middle Aged
Biocompatible material
Lipids
Anti-Bacterial Agents
chemistry
Biofilms
engineering
Female
Polyglycolic Acid
Norfloxacin
Biomedical engineering
Urethral catheter
Subjects
Details
- ISSN :
- 03785173
- Volume :
- 546
- Database :
- OpenAIRE
- Journal :
- International Journal of Pharmaceutics
- Accession number :
- edsair.doi.dedup.....099867a001d29105436a01ceb6e543f8