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How Did Zika Virus Emerge in the Pacific Islands and Latin America?
- Source :
- mBio, Vol 7, Iss 5, p e01239-16 (2016), mBio, mBio, American Society for Microbiology, 2016, 7 (5), pp.e01239-16. ⟨10.1128/mBio.01239-16⟩, mBio, 2016, 7 (5), pp.e01239-16. ⟨10.1128/mBio.01239-16⟩, mBio, Vol 7, Iss 5 (2016)
- Publication Year :
- 2016
- Publisher :
- American Society for Microbiology, 2016.
-
Abstract
- The unexpected emergence of Zika virus (ZIKV) in the Pacific Islands and Latin America and its association with congenital Zika virus syndrome (CZVS) (which includes microcephaly) and Guillain-Barré syndrome (GBS) have stimulated wide-ranging research. High densities of susceptible Aedes spp., immunologically naive human populations, global population growth with increased urbanization, and escalation of global transportation of humans and commercial goods carrying vectors and ZIKV undoubtedly enhanced the emergence of ZIKV. However, flavivirus mutations accumulate with time, increasing the likelihood that genetic viral differences are determinants of change in viral phenotype. Based on comparative ZIKV complete genome phylogenetic analyses and temporal estimates, we identify amino acid substitutions that may be associated with increased viral epidemicity, CZVS, and GBS. Reverse genetics, vector competence, and seroepidemiological studies will test our hypothesis that these amino acid substitutions are determinants of epidemic and neurotropic ZIKV emergence.
- Subjects :
- 0301 basic medicine
Microcephaly
Latin Americans
Guillain-Barre Syndrome
Pacific Islands
Genome
Microbiology
Microbiology in the medical area
Zika virus
03 medical and health sciences
Aedes
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Virology
Mikrobiologi inom det medicinska området
medicine
Animals
Humans
zika virus
Epidemics
Genetics
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology
[SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases
biology
Phylogenetic tree
Zika Virus Infection
Opinion/Hypothesis
16. Peace & justice
biology.organism_classification
medicine.disease
Reverse genetics
QR1-502
3. Good health
Flavivirus
030104 developmental biology
Vector (epidemiology)
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Americas
Subjects
Details
- Language :
- English
- ISSN :
- 21507511 and 21612129
- Volume :
- 7
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- mBio
- Accession number :
- edsair.doi.dedup.....099b5be9003d8ce99ee78787db113593