Back to Search
Start Over
Prognostic molecular markers with no impact on decision-making: the paradox of gliomas based on a prospective study
- Source :
- British Journal of Cancer, British Journal of Cancer, Cancer Research UK, 2008, 98 (11), pp.1830-8. ⟨10.1038/sj.bjc.6604378⟩
- Publication Year :
- 2008
-
Abstract
- International audience; This study assessed the prognostic value of several markers involved in gliomagenesis, and compared it with that of other clinical and imaging markers already used. Four-hundred and sixteen adult patients with newly diagnosed glioma were included over a 3-year period and tumour suppressor genes, oncogenes, MGMT and hTERT expressions, losses of heterozygosity, as well as relevant clinical and imaging information were recorded. This prospective study was based on all adult gliomas. Analyses were performed on patient groups selected according to World Health Organization histoprognostic criteria and on the entire cohort. The endpoint was overall survival, estimated by the Kaplan-Meier method. Univariate analysis was followed by multivariate analysis according to a Cox model. p14(ARF), p16(INK4A) and PTEN expressions, and 10p 10q23, 10q26 and 13q LOH for the entire cohort, hTERT expression for high-grade tumours, EGFR for glioblastomas, 10q26 LOH for grade III tumours and anaplastic oligodendrogliomas were found to be correlated with overall survival on univariate analysis and age and grade on multivariate analysis only. This study confirms the prognostic value of several markers. However, the scattering of the values explained by tumour heterogeneity prevents their use in individual decision-making.
- Subjects :
- Oncology
Cancer Research
Pathology
Multivariate analysis
[SDV]Life Sciences [q-bio]
Loss of Heterozygosity
markers
0302 clinical medicine
80 and over
LOH
Prospective Studies
Prospective cohort study
Promoter Regions, Genetic
DNA Modification Methylases
Telomerase
Aged, 80 and over
0303 health sciences
Univariate analysis
biology
Brain Neoplasms
Glioma
Middle Aged
DNA Repair Enzymes/genetics
Prognosis
3. Good health
[SDV] Life Sciences [q-bio]
030220 oncology & carcinogenesis
Cohort
DNA Modification Methylases/genetics
Promoter Regions (Genetics)
Adult
medicine.medical_specialty
Tumour heterogeneity
Decision Making
RT-PCR
Tumor Suppressor Proteins/genetics
outcome prediction
03 medical and health sciences
Cyclin-Dependent Kinase Inhibitor p16/genetics
Glioma/genetics/mortality
Internal medicine
medicine
PTEN
Humans
neoplasms
Molecular Diagnostics
Cyclin-Dependent Kinase Inhibitor p16
030304 developmental biology
Aged
Proportional hazards model
Tumor Suppressor Proteins
decision-making
DNA Methylation
medicine.disease
Telomerase/genetics
DNA Repair Enzymes
Brain Neoplasms/genetics/mortality
Multivariate Analysis
biology.protein
adult gliomas
Subjects
Details
- ISSN :
- 15321827 and 00070920
- Volume :
- 98
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- British journal of cancer
- Accession number :
- edsair.doi.dedup.....09baa4fa38fc88ce8011553117da9f77