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Distinct Skin Microbiota Imbalance and Responses to Clinical Treatment in Children With Atopic Dermatitis
- Source :
- Frontiers in Cellular and Infection Microbiology, Vol 10 (2020), Frontiers in Cellular and Infection Microbiology
- Publication Year :
- 2020
- Publisher :
- Frontiers Media SA, 2020.
-
Abstract
- Background: Atopic dermatitis (AD) is a common cutaneous disease, associated with imbalances in the skin microbiota. Objective: To explore the characteristics of the cutaneous microbiota and its dynamic changes during clinical treatment. Methods: Cutaneous swab samples were collected from 51 AD patients before treatment, and 40 AD patients remained after a 2-week treatment with mometasone and mupirocin. Results: AD patients exhibited significant enrichments of Prevotella and Desulfovibrio as well as obvious reductions of Corynebacterium, Streptococcus and Parabacteroides. Based on the proportion of Staphylococcus aureus, the AD patients were further classified into S. aureus-predominant group (AD.S) and S. aureus-non-dominant (AD.ND) group. The AD.S group exhibited lower skin microbial diversity and higher atopic dermatitis (SCORAD) index. In the AD.S group, the cutaneous microbial diversity significantly increased from 2.9 ± 0.8 to 3.7 ± 1.0, while the relative abundance of S. aureus decreased from 42.5 ± 20.7 to 10.3 ± 28.4 after treatment. In contrast, no significant skin microbiota changes were detected in the AD.ND group. Conclusions: AD patients with predominant S. aureus had higher disease severity and lower microbiota diversity compared to patients in the AD.ND group. Mometasone and mupirocin therapy had significant effects on skin microbiota in AD.S patients, but had a paradoxical response in the AD.ND patients.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Staphylococcus aureus
China
030106 microbiology
Immunology
lcsh:QR1-502
Corynebacterium
Mupirocin
medicine.disease_cause
Microbiology
lcsh:Microbiology
Dermatitis, Atopic
03 medical and health sciences
chemistry.chemical_compound
Cellular and Infection Microbiology
children
skin microbiota imbalance
medicine
Prevotella
Humans
SCORAD
Child
Original Research
Skin
atopic dermatitis
medicine.diagnostic_test
biology
business.industry
Streptococcus
Microbiota
Paradoxical reaction
Atopic dermatitis
Staphylococcal Infections
medicine.disease
biology.organism_classification
030104 developmental biology
Infectious Diseases
chemistry
clinical treatment
business
Subjects
Details
- ISSN :
- 22352988
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in Cellular and Infection Microbiology
- Accession number :
- edsair.doi.dedup.....09d5b3b9be7392c5460650778898e2ac