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Use of etanercept to treat rheumatoid arthritis in an HIV-positive patient: a case-based review
- Source :
- Rheumatology International. 37:1207-1212
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Rheumatoid arthritis (RA) is a relatively common autoimmune disease that is associated with progressive disability and systemic complications, with a relatively high socioeconomic burden. The treatment of RA has been revolutionized by the use of biological drugs, such as anti-tumor necrosis factor (TNF) agents. A wide spectrum of RA disease severity has been reported among patients with human immunodeficiency virus (HIV) infection. Yet, only a few cases using anti-TNF therapy have been described in this clinical population. Therefore, the aim of our case-based review was to describe the successful use of etanercept in a 38-year-old female patient with RA concomitant with HIV infection, who had been resistant to the first-line anti-rheumatic therapies. As per routine care guidelines, the patient was screened for hepatitis virus infection, latent tuberculosis, and other infectious conditions, prior to the initiation of etanercept treatment. CD4 cell count, HIV viral load, and adverse effects were closely monitored during the treatment. The HIV infection remained stable with etanercept treatment, without the need for anti-retrovirus agents. No adverse effects and serious infections were identified during the treatment. Therefore, anti-TNF therapy is a viable alternative for the treatment of RA in patients with HIV, who do not respond to conventional anti-rheumatic therapies. The relationship between TNF-α and HIV infection, as well as cautionary guidelines regarding the utilization of anti-TNF therapy in this clinical population, is discussed.
- Subjects :
- Adult
medicine.medical_specialty
Time Factors
Immunology
Population
HIV Infections
Etanercept
Arthritis, Rheumatoid
03 medical and health sciences
0302 clinical medicine
Rheumatology
Internal medicine
medicine
Humans
Immunology and Allergy
030212 general & internal medicine
education
Adverse effect
030203 arthritis & rheumatology
education.field_of_study
Latent tuberculosis
Tumor Necrosis Factor-alpha
business.industry
Viral Load
medicine.disease
CD4 Lymphocyte Count
Antirheumatic Agents
Treatment Outcome
Rheumatoid arthritis
Female
business
Viral load
medicine.drug
Subjects
Details
- ISSN :
- 1437160X and 01728172
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Rheumatology International
- Accession number :
- edsair.doi.dedup.....09d5fb0c86c80fa2c8dc74d1dbe003bf