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Accurate prediction of drug-induced heterogeneous response of red cell in vivo using a gravity-driven flow cytometry based on a microfluidic chip
- Source :
- Analytica chimica acta. 1221
- Publication Year :
- 2022
-
Abstract
- The drug-induced diverse response among patients is a severe problem for improving hemorheological character. However, there is no validated method for personalized therapy to the best of our knowledge. Here, we apply a gravity-driven deformability cytometry platform (GD-DCP) to profile the drug response of the red cell deformability (RCD) at the single-cell level using pentoxifylline (PTX) as a model drug, the effect of different concentrations of PTX (0, 2, 20, 200 μg mL
Details
- ISSN :
- 18734324
- Volume :
- 1221
- Database :
- OpenAIRE
- Journal :
- Analytica chimica acta
- Accession number :
- edsair.doi.dedup.....09d8fd45c62da0d8a036a00a8ba19da0