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Renal Function in Analgesic Nephropathy
- Source :
- BMJ. 2:213-216
- Publication Year :
- 1969
- Publisher :
- BMJ, 1969.
-
Abstract
- Comprehensive one-day renal function tests in 20 patients with a history of analgesic abuse showed varying degrees of chronic renal failure in all. There was no evidence of a selective defect in proximal tubular function, while a defective concentrating mechanism, usually considered necessary for the diagnosis of analgesic-induced renal damage, could be demonstrated in only 16 patients. A urinary acidification defect associated with a concentrating defect was found in nine cases and was thought to reflect specific collecting duct dysfunction. Urinary ammonium excretion was reduced in 13 subjects, owing to a reduced number of functioning nephrons or inadequate acidification, or both. Low citrate excretion was frequently encountered, and this, as well as defective urinary acidification, may play some part in predisposing patients with analgesic nephropathy to intrarenal calcification and progressive renal failure.
- Subjects :
- Adult
Male
medicine.medical_specialty
Substance-Related Disorders
Vasopressins
Urinary system
Urology
Renal function
Kidney Function Tests
Kidney Concentrating Ability
Excretion
Internal medicine
medicine
Humans
Citrates
Analgesic abuse
Aged
General Environmental Science
Acid-Base Equilibrium
Analgesics
business.industry
General Engineering
Papers and Originals
General Medicine
Acute Kidney Injury
Middle Aged
Analgesic nephropathy
medicine.disease
Progressive renal failure
Endocrinology
Creatinine
General Earth and Planetary Sciences
Chronic renal failure
Female
business
Glomerular Filtration Rate
Calcification
Subjects
Details
- ISSN :
- 14685833 and 09598138
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- BMJ
- Accession number :
- edsair.doi.dedup.....09dddf4b97d3988ece8a03d19a9ab2b7