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Supplementary Tables from Fusion Kinases Identified by Genomic Analyses of Sporadic Microsatellite Instability–High Colorectal Cancers

Authors :
Hiroyuki Mano
Toshiaki Watanabe
Hiroyuki Aburatani
Masashi Fukayama
Hisae Iinuma
Yoshihiro Yamashita
Eirin Sai
Shinji Kohsaka
Takafumi Oga
Manabu Soda
Hiroyuki Abe
Genta Nagae
Shinya Kojima
Toshihide Ueno
Yoko Yamamoto
Masahito Kawazu
Kazuhito Sato
Publication Year :
2023
Publisher :
American Association for Cancer Research (AACR), 2023.

Abstract

Supplementary Tables S1-S12: Supplementary Table S1: Primer sequences used in this study. Supplementary Table S2: Clinical information of tumours analysed in the present study. Supplementary Table S3: Patients' characteristics. Supplementary Table S4: Likely causal mutations in mismatch repair genes detected in this study. Supplementary Table S5: List of Tier 2 mutations. Supplementary Table S6: Significantly mutated genes identified with MutSigCV. Supplementary Table S7: Genes differentially altered between Lynch syndrome-associated/Lynch-like tumours and MLH1 promoter-methylated tumours. Supplementary Table S8: Recurrent copy number alterations detected with allele-specific copy number analysis. Supplementary Table S9: Pathways detected from top 209 Tier 2 genes with The Database for Annotation, Visualization and Integrated Discovery. Supplementary Table S10: Pathways detected from significantly mutated genes with The Database for Annotation, Visualization and Integrated Discovery. Supplementary Table S11: Detected oncogenic alterations and associated mutations with uncertain significance. Supplementary Table S12: Complementary DNA sequences of fusion points confirmed by reverse-transcription polymerase chain reaction followed by Sanger sequencing.

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....09ee4d3885121e32029c75a83ced960a
Full Text :
https://doi.org/10.1158/1078-0432.22473842