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Prevalence and predictors of low muscle mass in HIV/viral hepatitis coinfection
- Source :
- AIDS. 30:2519-2528
- Publication Year :
- 2016
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2016.
-
Abstract
- Objective Low muscle mass is associated with reduced survival in HIV, possibly mediated by systemic inflammation. Viral hepatitis coinfection can induce additional inflammation and hepatic dysfunction that may exacerbate low muscle mass. We determined the prevalence of and risk factors for low muscle mass in HIV/viral hepatitis coinfection. Design and methods A cross-sectional study of participants in the Multicenter AIDS Cohort Study and Women's Interagency HIV Study with anthropometry performed after 1 January 2000. Viral hepatitis defined by positive hepatitis B virus surface antigen and/or hepatitis C virus RNA. Low muscle mass defined as less than 10th percentile of age-matched and sex-matched reference values for mid-upper arm circumference. Using multivariable logistic regression, we determined adjusted odds ratios with 95% confidence intervals (CIs) of the association of HIV/viral hepatitis coinfection with low muscle mass and factors associated with low muscle mass in coinfected persons. Analyses adjusted for age, race, BMI, alcohol use, and IDU (also, nadir CD4 cell count and HIV RNA where appropriate). Results Among 3518 participants (164 HIV/viral hepatitis, 223 viral hepatitis alone, 1070 HIV alone, and 2061 uninfected), HIV/viral hepatitis-coinfected persons had a 3.50-fold (95% CI, 1.51-8.09), 1.93-fold (1.17-3.20), and 2.65-fold (1.62-4.35) higher odds of low muscle mass than viral hepatitis-monoinfected, HIV-monoinfected, and uninfected persons, respectively. Lack of HIV RNA suppression [odds ratio, 2.26 (95% CI, 1.10-4.63)] was the only factor associated with low muscle mass in coinfected persons. Conclusion HIV/viral hepatitis-coinfected persons have a higher likelihood of low muscle mass than those with viral hepatitis monoinfection, HIV monoinfection, or neither infection. HIV viremia is an important risk factor for low muscle mass among coinfected persons.
- Subjects :
- Adult
Male
Immunology
Multicenter AIDS Cohort Study
HIV Infections
Article
03 medical and health sciences
Hepatitis B, Chronic
0302 clinical medicine
Risk Factors
Prevalence
medicine
Humans
Immunology and Allergy
030212 general & internal medicine
Anthropometry
Coinfection
business.industry
Hepatitis C
Women's Interagency HIV Study
Odds ratio
Hepatitis C, Chronic
Middle Aged
Hepatitis B
medicine.disease
Virology
Muscular Atrophy
Cross-Sectional Studies
Infectious Diseases
Sarcopenia
Female
030211 gastroenterology & hepatology
business
Viral hepatitis
Subjects
Details
- ISSN :
- 02699370
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- AIDS
- Accession number :
- edsair.doi.dedup.....09f1e20276042adae8e810576efb9787