Additional file 2: of HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia

Figure S1. Main features of RNA-Seq data; Figure S2. Differentially expressed genes in shHIF1A NX vs shCTR NX and in shHIF1A HYP vs shCTR HYP gene sets; Figure S3. Validation of RNAseq data by RT-PCR in SHSY5Y cells; Figure S4. Correlation of DNA methylation and gene expression; Figure S5. Genes differentially expressed and methylated under hypoxia and associated with NB survival; Figure S6. Survival analysis of NB patients based on the gene expression of candidate targets of putative enhancers differentially regulated in hypoxia. Figure S7. Survival analysis of NB patients based on the gene expression of candidate targets of putative enhancers differentially regulated in hypoxia. (DOCX 7156 kb)