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Identification of diverse viruses in upper respiratory samples in dromedary camels from United Arab Emirates
- Source :
- PLoS ONE, PLoS ONE, Vol 12, Iss 9, p e0184718 (2017), PLOS ONE
- Publication Year :
- 2017
-
Abstract
- Camels are known carriers for many viral pathogens, including Middle East respiratory syndrome coronavirus (MERS-CoV). It is likely that there are additional, as yet unidentified viruses in camels with the potential to cause disease in humans. In this study, we performed metagenomic sequencing analysis on nasopharyngeal swab samples from 108 MERS-CoV-positive dromedary camels from a live animal market in Abu Dhabi, United Arab Emirates. We obtained a total of 846.72 million high-quality reads from these nasopharyngeal swab samples, of which 2.88 million (0.34%) were related to viral sequences while 512.63 million (60.5%) and 50.87 million (6%) matched bacterial and eukaryotic sequences, respectively. Among the viral reads, sequences related to mammalian viruses from 13 genera in 10 viral families were identified, including Coronaviridae, Nairoviridae, Paramyxoviridae, Parvoviridae, Polyomaviridae, Papillomaviridae, Astroviridae, Picornaviridae, Poxviridae, and Genomoviridae. Some viral sequences belong to known camel or human viruses and others are from potentially novel camel viruses with only limited sequence similarity to virus sequences in GenBank. A total of five potentially novel virus species or strains were identified. Co-infection of at least two recently identified camel coronaviruses was detected in 92.6% of the camels in the study. This study provides a comprehensive survey of viruses in the virome of upper respiratory samples in camels that have extensive contact with the human population.
- Subjects :
- 0301 basic medicine
RNA viruses
Coronaviruses
viruses
lcsh:Medicine
medicine.disease_cause
Pathology and Laboratory Medicine
Camels
Zoonoses
Bunyaviruses
Medicine and Health Sciences
Coronaviridae
lcsh:Science
Hemorrhagic fever viruses
Phylogeny
Data Management
Mammals
education.field_of_study
Viral Genomics
Multidisciplinary
Mammalian Genomics
biology
Phylogenetic Analysis
Genomics
Phylogenetics
Virus Diseases
Medical Microbiology
Viral Pathogens
Vertebrates
Viruses
Pathogens
Research Article
endocrine system
Computer and Information Sciences
Camelus
Paramyxoviridae
Middle East respiratory syndrome coronavirus
030106 microbiology
Population
United Arab Emirates
Microbial Genomics
Microbiology
03 medical and health sciences
Virology
medicine
Genetics
Animals
Humans
Human virome
Evolutionary Systematics
education
Microbial Pathogens
Taxonomy
Parvoviridae
Evolutionary Biology
lcsh:R
Organisms
Biology and Life Sciences
Sequence Analysis, DNA
biology.organism_classification
Polyomaviridae
Polyomaviruses
Crimean-Congo hemorrhagic fever virus
030104 developmental biology
Animal Genomics
Novel virus
Amniotes
lcsh:Q
Metagenomics
DNA viruses
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....0a39dde0f64a1b6f81e608a46ffcb30c