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A randomized, comparative study of a single oral dose of fluconazole versus a single topical dose of clotrimazole in the treatment of vaginal candidosis among general practitioners and gynaecologists
- Source :
- European Journal of Obstetrics & Gynecology and Reproductive Biology. 55:123-127
- Publication Year :
- 1994
- Publisher :
- Elsevier BV, 1994.
-
Abstract
- Objectives: To compare efficacy, acceptability and patient preference of a single oral dose of fluconazole with a single intravaginal dose of 500 mg clotrimazole (medication groups) in women with vaginal candidosis visiting gynaecologists or general practitioners (study groups). Design : A comparative, randomized multicenter study. Events: Baseline visit and treatment, short-term follow-up after 1 week and long-term follow-up after 4 weeks. At each visit, symptoms were graded and cultures were obtained. Results: Symptomatic and mycological efficacy did not differ statistical significant in the medication groups or study groups. A complicated history regarding vaginal candidosis was more often found among gynaecologists, yielding poorer results of treatment. Patients preferred oral treatment over intra-vaginal treatment. Conclusions: No differences were found in the clinical and mycological efficacy of both drugs. Clinical results were related to parameters originating from the patients history, resulting in less favourable results in the study group of gynaecologists.
- Subjects :
- Adult
medicine.medical_specialty
Adolescent
Administration, Oral
law.invention
Patient satisfaction
Pharmacotherapy
Vaginal disease
Randomized controlled trial
law
Internal medicine
Humans
Medicine
Clotrimazole
Fluconazole
Candidiasis, Vulvovaginal
Aged
Gynecology
business.industry
Obstetrics and Gynecology
Middle Aged
Clinical trial
Administration, Intravaginal
medicine.anatomical_structure
Reproductive Medicine
Patient Satisfaction
Vagina
Female
Family Practice
business
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 03012115
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- European Journal of Obstetrics & Gynecology and Reproductive Biology
- Accession number :
- edsair.doi.dedup.....0a44c84833557415abbd8e9fe02f4076
- Full Text :
- https://doi.org/10.1016/0028-2243(94)90066-3