Neuropathological differences between familial Alzheimer’s disease (FAD) caused by Presenilin mutation E280A and sporadic Alzheimer’s disease (SAD)

Introduction: Even though less than 1% of Alzheimer’s disease (AD) is of hereditary origin, FAD is used as a reference for its natural history and as a framework for the development of animal models and therapies for the disease. Given that all known mutations for FAD occur in proteins involved[for full text, please go to the a.m. URL]
60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)