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Evaluation of radiation dose to anthropomorphic paediatric models from positron-emitting labelled tracers
- Source :
- Physics in Medicine and Biology, 59(5). IOP PUBLISHING LTD, Physics in Medicine and Biology, Vol. 59, No 5 (2014) pp. 1165-87, Physics in medicine and biology
- Publication Year :
- 2014
-
Abstract
- PET uses specific molecules labelled with positron-emitting radionuclides to provide valuable biochemical and physiological information. However, the administration of radiotracers to patients exposes them to low-dose ionizing radiation, which is a concern in the paediatric population since children are at a higher cancer risk from radiation exposure than adults. Therefore, radiation dosimety calculations for commonly used positron-emitting radiotracers in the paediatric population are highly desired. We evaluate the absorbed dose and effective dose for 19 positron-emitting labelled radiotracers in anthropomorphic paediatric models including the newborn, 1-, 5-, 10- and 15-year-old male and female. This is achieved using pre-calculated S-values of positron-emitting radionuclides of UF-NCI paediatric phantoms and published biokinetic data for various radiotracers. The influence of the type of anthropomorphic model, tissue weight factors and direct human-versus mouse-derived biokinetic data on the effective dose for paediatric phantoms was also evaluated. In the case of F-18-FDG, dosimetry calculations of reference paediatric patients from various dose regimens were also calculated. Among the considered radiotracers, F-18-FBPA and O-15-water resulted in the highest and lowest effective dose in the paediatric phantoms, respectively. The ICRP 103 updated tissue-weighting factors decrease the effective dose in most cases. Substantial differences of radiation dose were observed between direct human-versus mouse-derived biokinetic data. Moreover, the effect of using voxel-versus MIRD-type models on the calculation of the effective dose was also studied. The generated database of absorbed organ dose and effective dose for various positron-emitting labelled radiotracers using new generation computational models and the new ICRP tissue-weighting factors can be used for the assessment of radiation risks to paediatric patients in clinical practice. This work also contributes to a better understanding of the factors influencing patient-specific radiation dose calculation.
- Subjects :
- Male
Aging
CHILDREN
SOFTWARE
Whole-Body Counting
Effective dose (radiation)
Ionizing radiation
Positron
Whole-Body Counting/methods
Biomimetic Materials
Medicine
Child
Monte Carlo
Paediatric patients
NUCLEAR-MEDICINE
Radiological and Ultrasound Technology
Phantoms, Imaging
DOSIMETRY
F-18-FDG PET/CT
CANCER
radiotracers
3. Good health
RECEPTORS
Organ Specificity
Absorbed dose
Child, Preschool
Isotope Labeling
Female
Adolescent
Electrons
Radiation Dosage
ddc:616.0757
Models, Biological
paediatrics
MALIGNANCIES
Positron-Emission Tomography/instrumentation/methods
Dosimetry
Humans
Radiology, Nuclear Medicine and imaging
Computer Simulation
Radioactive Tracers
Radioisotopes
business.industry
AREA IF HEIGHT
Radiation dose
Infant
Radioisotopes/analysis/diagnostic use
Aging/physiology
radiation dosimetry
PET
Positron-Emission Tomography
WEIGHT
business
Nuclear medicine
Paediatric population
Subjects
Details
- Language :
- English
- ISSN :
- 00319155
- Database :
- OpenAIRE
- Journal :
- Physics in Medicine and Biology, 59(5). IOP PUBLISHING LTD, Physics in Medicine and Biology, Vol. 59, No 5 (2014) pp. 1165-87, Physics in medicine and biology
- Accession number :
- edsair.doi.dedup.....0a887572d48835296ba0bb286b2ca789