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A dynamic nomogram for predicting diabetic macular edema in type 2 diabetes patients based on plasma cytokines
- Source :
- Aging (Albany NY)
- Publication Year :
- 2021
- Publisher :
- Impact Journals, LLC, 2021.
-
Abstract
- Objective This study investigated changes of plasma cytokines and aimed to build a dynamic nomogram for diabetic macular edema (DME) in type 2 diabetes mellitus (T2DM). Methods In a pilot cohort, plasma samples were selected from 9 T2DM patients and 9 DME patients to screen for cytokine differences. The screening cytokines were then validated by enzyme-linked immunoassay in a cohort, which contained 100 DME (DME group) and 100 T2DM patients without DME (T2DM group). A dynamic nomogram for predicting DME was developed, based on the plasma cytokines. Results In the pilot cohort, 11 plasma cytokines were significantly increased in the DME group. In the validation cohort, platelet-derived growth factor (PDGF)-BB, tissue inhibitors of metalloproteinase (TIMP)-1, angiopoietin (ANG-1), and vascular endothelial cell growth factor receptor (VEGFR)-2 were confirmed to be significantly elevated in the DME group. The dynamic nomogram demonstrated good calibration and discrimination, with an area under the receiver operating characteristic curve (AUC) of 0.88. In the test set, sensitivity, specificity, and AUC were 73.3%, 80.0%, and 0.84, respectively. Conclusion Plasma cytokines were closely associated with DME. A novel dynamic monogram including ANG-1, PDGF-BB, TIMP-1, and VEGFR2 was a novel tool for predicting DME.
- Subjects :
- Adult
Male
Aging
medicine.medical_specialty
endocrine system diseases
genetic structures
type 2 diabetes mellitus
medicine.medical_treatment
Urology
Pilot Projects
Type 2 diabetes
Macular Edema
Cohort Studies
Angiopoietin
plasma cytokines
medicine
Humans
Aged
biology
Receiver operating characteristic
business.industry
Type 2 Diabetes Mellitus
Cell Biology
Middle Aged
Nomogram
medicine.disease
eye diseases
Nomograms
Cytokine
Diabetes Mellitus, Type 2
Cohort
biology.protein
Cytokines
Female
dynamic nomogram
diabetic macular edema
business
Biomarkers
Platelet-derived growth factor receptor
Research Paper
Subjects
Details
- ISSN :
- 19454589
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Aging
- Accession number :
- edsair.doi.dedup.....0a96a34d94f4461803cd21a8a3a325cc