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A homeotic gene cluster patterns the anteroposterior body axis of C. elegans
- Source :
- Cell. 74:29-42
- Publication Year :
- 1993
- Publisher :
- Elsevier BV, 1993.
-
Abstract
- In insects and vertebrates, clusters of Antennapedia class homeobox (HOM-C) genes specify anteroposterior body pattern. The nematode C. elegans also contains a small cluster of HOM-C genes, one of which has been shown to specify positional identity. Here we show that two additional C. elegans HOM-C genes also specify positional identity and that together these three HOM-C genes function along the anteroposterior axis in the same order as their homologs in other organisms. Thus, HOM-C-based pattern formation has been conserved in nematodes despite the many differences in morphology and embryology that distinguish them from other phyla. Each C. elegans HOM-C gene is responsible for a distinct body region; however, where their domains overlap, two HOM-C genes can act together to specify the fates of individual cells.
- Subjects :
- Genetics
Base Sequence
Sequence Homology, Amino Acid
biology
Molecular Sequence Data
Genes, Homeobox
Antennapedia
biology.organism_classification
General Biochemistry, Genetics and Molecular Biology
Cell Movement
Multigene Family
Gene cluster
Morphogenesis
Animals
Homeobox
Body region
Amino Acid Sequence
Caenorhabditis elegans
Homeotic gene
Gene
Function (biology)
Subjects
Details
- ISSN :
- 00928674
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- Cell
- Accession number :
- edsair.doi.dedup.....0a9e16196bf83943a4663498f17d2062