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Impact of Safety-Related Dose Reductions or Discontinuations on Sustained Virologic Response in HCV-Infected Patients: Results from the GUARD-C Cohort

Authors :
GUARD C, Study Group
Hassanein, T
Bakalos, G
Ahlers, S
Shiffman, Ml
Tallarico, L
Reddy, Kr
Orlandini, A
Ferenci, P
Derbala, M
Coppola, C
Foster, Gr
Basho, J
Shabanaj, G
Harxhi, A
Debzi, N
Afredj, N
Guessab, N
Mahindad, N
Mahiou, H
Aissaoui, M
Al Qameesh, J
Al Ghandoor, Z
Assene, C
Bastens, B
Brixko, C
Cool, M
De Galocsy, C
Delwaide, J
George, C
Laukens, P
Lefebvre, V
Mulkay, Jp
Nevens, F
Servais, B
Van Vlierberghe, H
Horsmans, Y
Henrion, J
Sprengers, D
Michielsen, P
Bourgeois, S
Lasser, L
Langlet, P
Robaeys, G
Martinet, Jp
Warzee, P
Hoste, P
Reynaert, H
Juriens, I
Decaestecker, J
Van Der Meersch, F
Janssens, F
Ahmetagic, S
Verhaz, A
Bevanda, M
Calkic, L
Ibrahimpasic, N
Mesihovic, R
Mello, Ce
Ruiz, Fj
Martins Junior, E
Ferraz, Ml
Silva, G
Mendes, C
Lyra, A
Silva, Mh
Gomide, G
Fernandes, Jc
Pereira, P
Correa, Mc
Teixeira, R
Yousry, A
Hanno, A
Gabr, M
Omar, A
Esmat, G
Karatapanis, S
Nikolopoulou, V
Giannoulis, G
Manolakopoulos, S
Elefsiniotis, I
Drakoulis, C
Dimitroulopoulos, D
Kanatakis, S
Ketikoglou, I
Mimidis, K
Evgenidis, N
Akriviades, E
Vafiadi Zoubouli, I
Tsianos, E
Mela, M
Orfanou, E
Mousoulis, G
Karagiannis, I
Manesis, E
Varga, M
Nemesánszky, E
Fried, K
Schuller, J
Szalay, F
Lengyel, G
Tornai, I
Banyai, T
Lesch, M
Nagy, I
Gervain, J
Tusnadi, A
Schneider, F
Szentgyörgyi, L
Hunyady, B
Vincze, A
Tolvaj, G
Varkonyi, I
Makkai, E
Enyedi, J
Racz, I
Hausinger, P
Váczi, Z
Patai, Á
Ozsvár, Z
Lakner, L
Ribiczey, P
Bhalla, A
Somani, S
Luaia, R
Rao, P
Philip, M
Lawate, P
Nagral, A
Sood, A
Parikh, S
Merat, S
Nassiri Toosi, M
Alavian, Sm
Zali, Mr
Daryani, Ne
Drenaggi, D
Attili, Af
Bandiera, F
Bassi, P
Bellati, G
Bellantani, S
Brunetto, MAURIZIA ROSSANA
Bruno, S
Castelli, F
Castellacci, R
Cattelan, Am
Colombo, M
Craxi, A
D'Angelo, S
Colombo, S
Demelia, L
Di Perri, G
Di Giacomo, A
Ferrari, C
Francisci, D
Casinelli, K
Ganga, R
Costa, C
Mangia, A
Russo, Fp
Matarazzo, F
Mazzella, G
Mazzeo, M
Memoli, M
Montalbano, M
Montalto, G
Pieri, A
Passariello, N
Picciotto, A
Pietrangelo, A
Pirisi, M
Quirino, T
Raimondo, G
Rapaccini, Gl
Rizzardini, G
Rizzetto, M
Russello, M
Sabusco, G
Santantonio, T
Soardo, G
Amedea, A
Verucchi, G
Vinelli, F
Zignego, Al
Zuin, M
Ascione, A
Vinci, M
Pigozzi, Mg
Tundo, P
Saracco, Gm
Amoroso, P
Andreoni, M
Colletta, C
Erne, E
Megna, As
Biglino, A
Chiriaco, P
Foti, G
Spinzi, G
D'Amico, E
Paik, Sw
Ahn, Sh
Lee, Yn
Kim, Y
Yang, J
Han, Sy
Varghese, R
Al Gharabally, A
Askar, H
Sharara, A
Yaghi, C
Rached, Aa
Houmani, Z
Zaarour, F
Dohaibi, A
Ivanovski, L
Joksimovic, N
Abbas, Z
Memon, S
Mohsin, A
Masood, S
Hashmi, Z
Halota, W
Deron, Z
Mazur, W
Flisiak, R
Lipczynski, A
Musialik, J
Piekarska, A
Augustyniak, K
Baka Cwierz, B
Simon, K
Gietka, A
Berak, H
Sieklucki, J
Radowska, D
Szlauer, B
Piekos, T
Olszok, I
Jablkowski, M
Orszulak, G
Warakomska, I
Aleixo, Mj
Valente, C
Macedo, G
Sarmento Castro, R
Roxo, F
Faria, T
Mansinho, K
Velez, J
Ramos, Jp
Guerreiro, H
Alberto, S
Monteverde, C
Serejo, F
Peixe, P
Malhado, J
Curescu, M
Streinu Cercel, A
Caruntu, F
Livia, H
Preotescu, L
Arama, V
Ancuta, I
Gheorghe, L
Stanciu, C
Trifan, A
Acalovschi, M
Andreica, V
Pascu, O
Lencu, M
Sporea, I
Olteanu, D
Ionita Radu, F
Fierbinteanu Braticevici, C
Motoc, A
Silaghi, R
Musat, M
Coman, F
Stan, M
Cijevschi, C
Miftode, E
Delic, D
Jesic, R
Nozic, D
Svorcan, P
Fabri, M
Konstantinovic, L
Pelemis, M
Jankovic, G
Todorovic, Z
Nagorni, A
Kupcova, V
Skladany, L
Szantova, M
Krkoska, D
Jarcuska, P
Schreter, I
Oltman, M
Bocakova, J
Bunganic, I
Holoman, J
Giguere, A
Abdou, A. M.
Basic (bio-) Medical Sciences
Gastroenterology
Laboratory of Molecullar and Cellular Therapy
Liver Cell Biology
Michielsen, Peter
GUARD-C Study Group
Graham R. Foster
Carmine Coppola
Moutaz Derbala
Peter Ferenci
Alessandra Orlandini
K. Rajender Reddy
Ludovico Tallarico
Mitchell L. Shiffman
Silke Ahler
Georgios Bakalo
Tarek Hassanein
GUARD-C Study Group: [..
Davide Drenaggi
Adolfo Francesco Attili
Franco Bandiera
Paolo Bassi
Giorgio Bellati
Stefano Bellantani
Maurizia Brunetto
Savino Bruno
Francesco Castelli
Roberto Castellacci
Anna Maria Cattelan
Massimo Colombo
Antonio Craxi
Salvatore D'angelo
Silvia Colombo
Luigi Demelia
Giovanni Di Perri
Antonio Di Giacomo
Carlo Ferrari
Daniela Francisci
Katia Casinelli
Roberto Ganga
Chiara Costa
Alessandra Mangia
Francesco Paolo Russo
Filippo Matarazzo
Giuseppe Mazzella
Maurizio Mazzeo
Massimo Memoli
Marzia Montalbano
Giuseppe Montalto
Alessandro Pieri
Nicola Passariello
Antonio Picciotto
Antonello Pietrangelo
Mario Pirisi
Tiziana Quirino
Giovanni Raimondo
Gian Ludovico Rapaccini
Giuliano Rizzardini
Mario Rizzetto
Maurizio Russello
Giuseppe Sabusco
Teresa Santantonio
Giorgio Soardo
Alessandri Amedea
Gabriella Verucchi
Francesco Vinelli
Anna Linda Zignego
Massimo Zuin
Antonio Ascione
Maria Vinci
Maria Graziella Pigozzi
Paolo Tundo
Giorgio Maria Saracco
Pietro Amoroso
Massimo Andreoni
Cosimo Colletta
Elke Erne
Angelo Salomone Megna
Alberto Biglino
Piergiorgio Chiriaco
Giuseppe Foti
Giancarlo Spinzi
Emilio D'amico
…]
Foster G.R.
Coppola C.
Derbala M.
Ferenci P.
Orlandini A.
Reddy K.R.
Tallarico L.
Shiffman M.L.
Ahlers S.
Bakalos G.
Hassanein T.
Basho J.
Shabanaj G.
Harxhi A.
Debzi N.
Afredj N.
Guessab N.
Mahindad N.
Mahiou H.
Aissaoui M.
Al Qameesh J.
Al Ghandoor Z.
Assene C.
Bastens B.
Brixko C.
Cool M.
De Galocsy C.
Delwaide J.
George C.
Laukens P.
Lefebvre V.
Mulkay J.-P.
Nevens F.
Servais B.
Van Vlierberghe H.
Horsmans Y.
Henrion J.
Sprengers D.
Michielsen P.
Bourgeois S.
Lasser L.
Langlet P.
Robaeys G.
Martinet J.-P.
Warzee P.
Hoste P.
Reynaert H.
Juriens I.
Decaestecker J.
Van Der Meersch F.
Janssens F.
Ahmetagic S.
Verhaz A.
Bevanda M.
Calkic L.
Ibrahimpasic N.
Mesihovic R.
Mello C.E.
Ruiz F.J.
Junior E.M.
Ferraz M.L.
Silva G.
Mendes C.
Lyra A.
Silva M.H.
Gomide G.
Fernandes J.C.
Pereira P.
Correa M.C.
Teixeira R.
Yousry A.
Hanno A.
Gabr M.
Omar A.
Esmat G.
Karatapanis S.
Nikolopoulou V.
Giannoulis G.
Manolakopoulos S.
Elefsiniotis I.
Drakoulis C.
Dimitroulopoulos D.
Kanatakis S.
Ketikoglou I.
Mimidis K.
Evgenidis N.
Akriviades E.
Vafiadi-Zoubouli I.
Tsianos E.
Mela M.
Orfanou E.
Mousoulis G.
Karagiannis I.
Manesis E.
Varga M.
Nemesanszky E.
Fried K.
Schuller J.
Szalay F.
Lengyel G.
Tornai I.
Banyai T.
Lesch M.
Nagy I.
Gervain J.
Tusnadi A.
Schneider F.
Szentgyorgyi L.
Hunyady B.
Vincze A.
Tolvaj G.
Varkonyi I.
Makkai E.
Enyedi J.
Racz I.
Hausinger P.
Vaczi Z.
Patai A.
Ozsvar Z.
Lakner L.
Ribiczey P.
Bhalla A.
Somani S.
Luaia R.
Rao P.
Philip M.
Lawate P.
Nagral A.
Sood A.
Parikh S.
Merat S.
Nassiri-Toosi M.
Alavian S.-M.
Zali M.R.
Daryani N.E.
Drenaggi D.
Attili A.F.
Bandiera F.
Bassi P.
Bellati G.
Bellantani S.
Brunetto M.
Bruno S.
Castelli F.
Castellacci R.
Cattelan A.M.
Colombo M.
Craxi A.
D'angelo S.
Colombo S.
Demelia L.
Di Perri G.
Di Giacomo A.
Ferrari C.
Francisci D.
Casinelli K.
Ganga R.
Costa C.
Mangia A.
Russo F.P.
Matarazzo F.
Mazzella G.
Mazzeo M.
Memoli M.
Montalbano M.
Montalto G.
Pieri A.
Passariello N.
Picciotto A.
Pietrangelo A.
Pirisi M.
Quirino T.
Raimondo G.
Rapaccini G.L.
Rizzardini G.
Rizzetto M.
Russello M.
Sabusco G.
Santantonio T.
Soardo G.
Amedea A.
Verucchi G.
Vinelli F.
Zignego A.L.
Zuin M.
Ascione A.
Vinci M.
Pigozzi M.G.
Tundo P.
Saracco G.M.
Amoroso P.
Andreoni M.
Colletta C.
Erne E.
Megna A.S.
Biglino A.
Chiriaco P.
Foti G.
Spinzi G.
D'amico E.
Paik S.W.
Ahn S.-H.
Lee Y.N.
Kim Y.
Yang J.
Han S.Y.
Varghese R.
Al Gharabally A.
Askar H.
Sharara A.
Yaghi C.
Abou Rached A.
Houmani Z.
Zaarour F.
Dohaibi A.
Ivanovski L.
Joksimovic N.
Abbas Z.
Memon S.
Mohsin A.
Masood S.
Hashmi Z.
Halota W.
Deron Z.
Mazur W.
Flisiak R.
Lipczynski A.
Musialik J.
Piekarska A.
Augustyniak K.
Baka-Cwierz B.
Simon K.
Gietka A.
Berak H.
Sieklucki J.
Radowska D.
Szlauer B.
Piekos T.
Olszok I.
Jablkowski M.
Orszulak G.
Warakomska I.
Aleixo M.J.
Valente C.
Macedo G.
Sarmento-Castro R.
Roxo F.
Faria T.
Mansinho K.
Velez J.
Ramos J.P.
Guerreiro H.
Alberto S.
Monteverde C.
Serejo F.
Peixe P.
Malhado J.
Curescu M.
Streinu-Cercel A.
Caruntu F.
Livia H.
Preotescu L.
Arama V.
Ancuta I.
Gheorghe L.
Stanciu C.
Trifan A.
Acalovschi M.
Andreica V.
Pascu O.
Lencu M.
Sporea I.
Olteanu D.
Ionita-Radu F.
Fierbinteanu-Braticevici C.
Motoc A.
Silaghi R.
Musat M.
Coman F.
Stan M.
Cijevschi C.
Miftode E.
Delic D.
Jesic R.
Nozic D.
Svorcan P.
Fabri M.
Konstantinovic L.
Pelemis M.
Jankovic G.
Todorovic Z.
Nagorni A.
Kupcova V.
Skladany L.
Szantova M.
Krkoska D.
Jarcuska P.
Schreter I.
Oltman M.
Bocakova J.
Bunganic I.
Holoman J.
Giguere A.
Abdou A.M.S.
UCL - SSS/IREC-Institut de recherche expérimentale et clinique
UCL - SSS/IREC/GAEN-Pôle d'Hépato-gastro-entérologie
UCL - (SLuc) Service de gastro-entérologie
Source :
PLoS ONE, PLOS ONE, PLoS ONE, Vol 11, Iss 3, p e0151703 (2016), PLoS One, Vol. 11, no. 3, p. e0151703 [1-20] (2016)
Publication Year :
2015

Abstract

Background: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. Methods: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA

Subjects

Subjects :
Genetics and Molecular Biology (all)
Male
Chronic Hepatitis
Hepacivirus
Ribavirin/adverse effects
Asthenia/chemically induced
Polyethylene Glycol
Biochemistry
Polyethylene Glycols
Body Mass Index
Chronic Liver Disease
0302 clinical medicine
Neutropenia/chemically induced
Interferon-alpha/adverse effects
Medicine
Chronic
lcsh:Science
Liver Diseases
virus diseases
Antiviral Agents/adverse effects
Cohort
Science & Technology - Other Topics
030211 gastroenterology & hepatology
Drug Therapy, Combination
Cohort study
Human
medicine.medical_specialty
Alpha interferon
Gastroenterology and Hepatology
Antiviral Agents
Microbiology
Dose-Response Relationship
03 medical and health sciences
Pharmacotherapy
Hepatitis C, Chronic/drug therapy
Dose Prediction Methods
Drug Therapy
Anemia/chemically induced
Humans
Hemoglobin
Aged
Medicine and health sciences
Biochemistry, Genetics and Molecular Biology (all)
Hepaciviru
Science & Technology
Dose-Response Relationship, Drug
Flaviviruses
lcsh:R
Organisms
Biology and Life Sciences
Proteins
medicine.disease
digestive system diseases
chemistry
Agricultural and Biological Sciences (all)
Withholding Treatment
Asthenia
Immunology
Proportional Hazards Model
lcsh:Q
Human medicine
RNA viruses
Physiology
lcsh:Medicine
Peginterferon-alfa
Polyethylene Glycols/adverse effects
Adult
Anemia
Cohort Studies
Female
Hepatitis C, Chronic
Host-Pathogen Interactions
Interferon-alpha
Middle Aged
Neutropenia
Outcome Assessment (Health Care)
Proportional Hazards Models
RNA, Viral
Recombinant Proteins
Ribavirin
Medicine (all)
chemistry.chemical_compound
Outcome Assessment, Health Care
Medicine and Health Sciences
030212 general & internal medicine
Viral
Pathology and laboratory medicine
Multidisciplinary
biology
Hepatitis C virus
Pharmaceutics
Hepatitis C
Hematology
Recombinant Protein
Outcome Assessment (Health Care)/methods
Medical microbiology
Host-Pathogen Interaction
Multidisciplinary Sciences
Physiological Parameters
Research Design
Combination
Viruses
Drug
Pathogens
Host-Pathogen Interactions/drug effects
Research Article
Clinical Research Design
Research and Analysis Methods
Internal medicine
Recombinant Proteins/adverse effects
RNA, Viral/blood
Antiviral Agent
business.industry
Body Weight
Hepacivirus/drug effects
Viral pathogens
biology.organism_classification
Hepatitis viruses
Microbial pathogens
RNA
Adverse Events
Cohort Studie
business

Details

ISSN :
19326203
Volume :
11
Issue :
3
Database :
OpenAIRE
Journal :
PloS one
Accession number :
edsair.doi.dedup.....0aa232bd60ef5b9e1f5fc68dc781a16d

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Authors Abstract Subjects Details