Back to Search
Start Over
Impact of mycotoxins on the intestine
- Source :
- Journal of Toxicology and Environmental Health, Part B: Critical Reviews, Journal of Toxicology and Environmental Health, Part B: Critical Reviews, Taylor & Francis, 2017, 20 (5), pp.249-275. ⟨10.1080/10937404.2017.1326071⟩
- Publication Year :
- 2017
- Publisher :
- HAL CCSD, 2017.
-
Abstract
- International audience; There is an increasing awareness of the deleterious effects attributed to mycotoxins during their fate within the gut, particularly for deoxynivalenol (DON), zearalenone (ZEN), ochratoxin A (OTA), fumonisin B1 (FB1), aflatoxin B1 (AFB1) and patulin (PAT). Disruption of the epithelial barrier is well-established. However, intestinal barrier function on its luminal side involves two other partners, mucus and microbiota which have rarely been considered in the context of mycotoxin exposure. The current review aimed at providing a summary of DON, ZEN, OTA, FB1, AFB1 and PAT effects on intestinal barrier function, with special focus on mucus and microbiota. DON, ZEN, OTA, FB1, AFB1 and PAT are known to markedly affect epithelial cell integrity and functions. Regarding mucus, DON is undoubtedly the most documentated mycotoxin. In vivo, toxicological impact of DON generally has only been assessed through goblet cell number. Evaluation of the mycotoxins/mucus interplay considering other indicators such as composition, thickness and penetrability of mucus, mucin Oglycosylation thus warrants further attention. With respect to microbiota, few short-term studies to date have been reported indicating deleterious effects. However, long-term exposure to mycotoxins may also produce significant changes in microbiota composition and metabolic activity, which requires further experimentation. In conclusion, mucus and microbiota are key targets for dietary mycotoxins although assessment of induced effects is preliminary. A significant research effort is now underway to determine the adverse consequences of mycotoxins on mucus and microbiota considered as individual but also as tightly-connected gut players.
- Subjects :
- 0301 basic medicine
Ochratoxin A
Aflatoxin B1
animal structures
Health, Toxicology and Mutagenesis
[SDV]Life Sciences [q-bio]
[SDV.TOX.TVM]Life Sciences [q-bio]/Toxicology/Vegetal toxicology and mycotoxicology
Context (language use)
[SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain
Biology
Toxicology
Fumonisins
Microbiology
03 medical and health sciences
chemistry.chemical_compound
fluids and secretions
Intestinal mucosa
mucus
medicine
microbiota
Animals
Humans
Intestinal Mucosa
Mycotoxin
Goblet cell
Fumonisin B1
[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
030102 biochemistry & molecular biology
Mucin
food and beverages
dietary mycotoxins
Mycotoxins
Mucus
Ochratoxins
3. Good health
Gastrointestinal Microbiome
Intestines
030104 developmental biology
medicine.anatomical_structure
Patulin
chemistry
dietary mycotoxins, gut, epithelium, mucus, microbiota
[SDV.TOX]Life Sciences [q-bio]/Toxicology
gut
Zearalenone
epithelium
Trichothecenes
Subjects
Details
- Language :
- English
- ISSN :
- 10937404 and 15216950
- Database :
- OpenAIRE
- Journal :
- Journal of Toxicology and Environmental Health, Part B: Critical Reviews, Journal of Toxicology and Environmental Health, Part B: Critical Reviews, Taylor & Francis, 2017, 20 (5), pp.249-275. ⟨10.1080/10937404.2017.1326071⟩
- Accession number :
- edsair.doi.dedup.....0aa40cf13ffcf89f4d5db8afbb75475d