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Hypertension and cardiovascular diseases in Swedish persons with haemophilia - A longitudinal registry study
- Source :
- Thrombosis research. 181
- Publication Year :
- 2019
-
Abstract
- Data on the prevalence of hypertension and cardiovascular diseases (CVD) among persons with haemophilia (PWH) vary. Sweden has a long tradition of maintaining population-based data registries, and there is extensive follow-up of haemophilia patients due to the use of prophylaxis over decades. We evaluated the prevalence of these diseases among Swedish PWH compared to matched controls using a longitudinal study design.Data were obtained from the National Patient Registry and linked to records of persons with haemophilia enrolled in the haemophilia centres. For each subject, five gender and age matched controls were identified.We identified 193 (19.7%) diagnoses of hypertension in PWH born in 1978 or earlier over ≥30 years compared with 550 (11.2%) among controls. The median ages and interquartile ranges were 60.0 (42.8, 69.9) and 57.2 (42.6, 70.6) years. The hazard rate (HR) for hypertension, PWH vs. controls, was 2.1, 95% CI: [1.8; 2.5], p 0.001. The findings were similar in subgroup analyses of patients with non-severe and severe haemophilia with or without HIV and/or viral hepatitis. Angina pectoris was diagnosed in 69 (4.8%) of patients censored at age 75 compared with 311 (4.3%) in controls, and myocardial ischemia in 84 (5.9%) compared with 442 (6.2%). As a cause of death, the HR for myocardial ischemia, comparing PWH and controls, was 0.58, 95% CI: [0.42, 0.80], p = 0.001.Our data support an increased prevalence of hypertension among persons with haemophilia. The prevalence of CVD seems to be similar to that of controls, but with lower mortality.
- Subjects :
- Adult
Male
Longitudinal study
Pediatrics
medicine.medical_specialty
Registry study
Population
Haemophilia A
030204 cardiovascular system & hematology
Haemophilia
Hemophilia A
03 medical and health sciences
Young Adult
0302 clinical medicine
Interquartile range
Risk Factors
Medicine
Humans
Longitudinal Studies
Registries
education
Aged
Hepatitis
Sweden
education.field_of_study
business.industry
Hazard ratio
Hematology
Middle Aged
medicine.disease
Cardiovascular Diseases
030220 oncology & carcinogenesis
Hypertension
Female
business
Subjects
Details
- ISSN :
- 18792472
- Volume :
- 181
- Database :
- OpenAIRE
- Journal :
- Thrombosis research
- Accession number :
- edsair.doi.dedup.....0ab3752f80328aca601d7262cf8da761