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Persistence of human papillomavirus type 16 infection is associated with lack of cytotoxic T lymphocyte response to the E6 antigens
- Source :
- The Journal of infectious diseases. 182(2)
- Publication Year :
- 2000
-
Abstract
- Our cross-sectional study suggested that cytotoxic T lymphocyte (CTL) responses have a protective effect in squamous intraepithelial lesion (SIL) development. More CTL responses in women with human papillomavirus type 16 (HPV 16) infection without SILs than with SILs were detected. In the current longitudinal study, the role of CTL in clearing HPV 16 infection in women without SILs was investigated. Women with HPV 16 infection (n=51) were enrolled, along with HPV 16-negative control women (n=3). Twenty-two (55%) of 40 women who cleared HPV 16 infection had an E6 CTL response at least once, compared with none of 9 women who had HPV 16 persistence (P=.003). Such a difference was not demonstrated for E7; 25 (63%) of 40 women who cleared HPV 16 infection responded, versus 5 (56%) of 9 women with persistence (P=.720). It appears that lack of response to E6 is important in the persistence of HPV 16 infection.
- Subjects :
- Adult
Cellular immunity
Adolescent
Biology
Cohort Studies
Immune system
Antigen
medicine
Immunology and Allergy
Cytotoxic T cell
Humans
Papillomaviridae
Papillomavirus Infections
virus diseases
T lymphocyte
Oncogene Proteins, Viral
medicine.disease
Virology
female genital diseases and pregnancy complications
Repressor Proteins
CTL
Squamous intraepithelial lesion
Tumor Virus Infections
Infectious Diseases
Immunology
Female
Viral disease
T-Lymphocytes, Cytotoxic
Subjects
Details
- ISSN :
- 00221899
- Volume :
- 182
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The Journal of infectious diseases
- Accession number :
- edsair.doi.dedup.....0ab65890ccd688f118f9187fefe5788b