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Cytomegalovirus (CMV) seroprevalence in the adult population of Germany
- Source :
- PLoS ONE, Vol 13, Iss 7, p e0200267 (2018), PLoS ONE
- Publication Year :
- 2018
- Publisher :
- Robert Koch-Institut, 2018.
-
Abstract
- Background: Infection with cytomegalovirus (CMV) remains asymptomatic in most immunocompetent hosts, but is the leading cause of congenital viral infection worldwide and can be life-threatening in immunocompromised individuals. We aimed to assess CMV seroprevalence in a nationally representative sample of adults in Germany and to identify sociodemographic factors associated with CMV seropositivity. Methods: Blood samples from 6552 participants (18–79 years) of the “German National Health Interview and Examination Survey 1998”, a population-based sample of the adult population in Germany, were tested for the presence of CMV antibodies using an Ig-multiplex assay. Weighted seroprevalence was calculated and weighted binomial regression was used to identify factors associated with CMV seropositivity. Results: Overall CMV seroprevalence was 56.7% (95%CI: 54.8–58.7%), with a higher seroprevalence in women (62.3%) than in men (51.0%). Seroprevalence increased with age: from 31.8% to 63.7% in men and from 44.1% to 77.6% in women when comparing the 18–29 with the 70–79 year age-group, respectively. CMV seroprevalence in women of childbearing age (18–45 years) was 51.7%. Factors significantly associated with CMV seropositivity were age, country of birth, smoking status, education, living in northern Germany and number of household members. In addition, having attended child care was associated with seropositivity in men, and number of siblings and living in East Germany in women. Conclusion: Our results indicate that half the women of childbearing age were susceptible for primary CMV infection during pregnancy. CMV screening during pregnancy and informing seronegative women about CMV risk reduction measures could prevent congenital CMV infections with its serious consequences.
- Subjects :
- Cytomegalovirus Infection
Male
0301 basic medicine
Human cytomegalovirus
Viral Diseases
European People
German People
Adult population
Cytomegalovirus
lcsh:Medicine
Pathology and Laboratory Medicine
Antibodies, Viral
Geographical locations
Families
Seroepidemiologic Studies
Germany
Medicine and Health Sciences
Ethnicities
Public and Occupational Health
lcsh:Science
Children
Vaccines
education.field_of_study
Child care
Multidisciplinary
virus diseases
Middle Aged
Europe
Infectious Diseases
Medical Microbiology
Viral Pathogens
Viruses
Cytomegalovirus Infections
Human Cytomegalovirus
Female
Pathogens
medicine.symptom
Research Article
Adult
Herpesviruses
Infectious Disease Control
Adolescent
Population
Congenital cytomegalovirus infection
Microbiology
Asymptomatic
Young Adult
03 medical and health sciences
medicine
Humans
Seroprevalence
European Union
ddc:610
education
Microbial Pathogens
Aged
Behavior
Pregnancy
Biology and life sciences
business.industry
lcsh:R
Organisms
medicine.disease
Health Surveys
030104 developmental biology
Age Groups
Population Groupings
lcsh:Q
People and places
DNA viruses
business
610 Medizin und Gesundheit
Demography
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, Vol 13, Iss 7, p e0200267 (2018), PLoS ONE
- Accession number :
- edsair.doi.dedup.....0ac761e759035b3d2a55936aad2442c4