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Erythropoietin Improves Atrophy, Bleeding and Cognition in the Newborn Intraventricular Hemorrhage
- Source :
- Frontiers in Cell and Developmental Biology, Front. Cell Dev. Biol. 8:571258, RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz, instname, Frontiers in Cell and Developmental Biology, Vol 8 (2020), RODIN: Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz, Universidad de Cádiz
- Publication Year :
- 2020
- Publisher :
- Frontiers Media SA, 2020.
-
Abstract
- The germinal matrix-intraventricular hemorrhage (GM-IVH) is one of the most devastating complications of prematurity. The short- and long-term neurodevelopmental consequences after severe GM-IVH are a major concern for neonatologists. These kids are at high risk of psychomotor alterations and cerebral palsy; however, therapeutic approaches are limited. Erythropoietin (EPO) has been previously used to treat several central nervous system complications due to its role in angiogenesis, neurogenesis and as growth factor. In addition, EPO is regularly used to reduce the number of transfusions in the preterm infant. Moreover, EPO crosses the blood-brain barrier and EPO receptors are expressed in the human brain throughout development. To analyze the role of EPO in the GM-IVH, we have administered intraventricular collagenase (Col) to P7 mice, as a model of GM-IVH of the preterm infant. After EPO treatment, we have characterized our animals in the short (14 days) and the long (70 days) term. In our hands, EPO treatment significantly limited brain atrophy and ventricle enlargement. EPO also restored neuronal density and ameliorated dendritic spine loss. Likewise, inflammation and small vessel bleeding were also reduced, resulting in the preservation of learning and memory abilities. Moreover, plasma gelsolin levels, as a feasible peripheral marker of GM-IVH-induced damage, recovered after EPO treatment. Altogether, our data support the positive effect of EPO treatment in our preclinical model of GM-IVH, both in the short and the long term.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
gelsolin
Angiogenesis
Central nervous system
Inflammation
preterm infant
03 medical and health sciences
Cell and Developmental Biology
0302 clinical medicine
Atrophy
Internal medicine
hemic and lymphatic diseases
Medicine
lcsh:QH301-705.5
Original Research
business.industry
Neurogenesis
Human brain
Cell Biology
medicine.disease
030104 developmental biology
Intraventricular hemorrhage
medicine.anatomical_structure
Endocrinology
lcsh:Biology (General)
Erythropoietin
030220 oncology & carcinogenesis
neuronal loss
erythropoietin
medicine.symptom
business
germinal matrix-intraventricular hemorrhage
brain atrophy
medicine.drug
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 2296634X
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Frontiers in Cell and Developmental Biology
- Accession number :
- edsair.doi.dedup.....0ad9a13874521fdc9c91d269b0c099b5
- Full Text :
- https://doi.org/10.3389/fcell.2020.571258