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Potential Mechanisms Underlying Intercortical Signal Regulation via Cholinergic Neuromodulators
- Source :
- The Journal of Neuroscience. 35:15000-15014
- Publication Year :
- 2015
- Publisher :
- Society for Neuroscience, 2015.
-
Abstract
- The dynamical behavior of the cortex is extremely complex, with different areas and even different layers of a cortical column displaying different temporal patterns. A major open question is how the signals from different layers and different brain regions are coordinated in a flexible manner to support function. Here, we considered interactions between primary auditory cortex and adjacent association cortex. Using a biophysically based model, we show how top-down signals in the beta and gamma regimes can interact with a bottom-up gamma rhythm to provide regulation of signals between the cortical areas and among layers. The flow of signals depends on cholinergic modulation: with only glutamatergic drive, we show that top-down gamma rhythms may block sensory signals. In the presence of cholinergic drive, top-down beta rhythms can lift this blockade and allow signals to flow reciprocally between primary sensory and parietal cortex.SIGNIFICANCE STATEMENTFlexible coordination of multiple cortical areas is critical for complex cognitive functions, but how this is accomplished is not understood. Using computational models, we studied the interactions between primary auditory cortex (A1) and association cortex (Par2). Our model is capable of replicating interaction patterns observedin vitroand the simulations predict that the coordination between top-down gamma and beta rhythms is central to the gating process regulating bottom-up sensory signaling projected from A1 to Par2 and that cholinergic modulation allows this coordination to occur.
- Subjects :
- Cerebral Cortex
General Neuroscience
Posterior parietal cortex
Sensory system
Articles
Biology
Auditory cortex
Cholinergic Neurons
medicine.anatomical_structure
Cerebral cortex
Neural Pathways
Gamma Rhythm
medicine
Humans
Cholinergic
Neural Networks, Computer
Cholinergic neuron
Beta Rhythm
Neuroscience
Cortical column
Signal Transduction
Subjects
Details
- ISSN :
- 15292401 and 02706474
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- The Journal of Neuroscience
- Accession number :
- edsair.doi.dedup.....0ae2cd14646e5c7bebd8245ea210e073