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Effects of urotensin-II on cytokines in early acute liver failure in mice
- Source :
- World journal of gastroenterology. 21(11)
- Publication Year :
- 2014
-
Abstract
- AIM: To investigate urotensin-II (UII) and its effects on tumor necrosis factor (TNF)-α and interleukin (IL)-1β in early acute liver failure (ALF). METHODS: We investigated the time-dependent alteration in UII levels and its effects on TNF-α and IL-1β in liver and blood in the early stage of lipopolysaccharide/D-galactosamine-induced ALF. RESULTS: After lipopolysaccharide/D-galactosamine challenge, UII rose very rapidly and reached a maximal level 0.5 h, and the level remained significantly elevated after 2 h (P < 0.05). Six hours after challenge, UII began to degrade, but remained higher than at 0 h (P < 0.05). Pretreatment with urantide, an inhibitor of the UII receptor, suppressed the degree of UII increase in liver and blood at 6 h after challenge (P < 0.05 vs paired controls). In addition, liver and blood TNF-α increased from 1 to 6 h, and reached a peak at 1 and 2 h, respectively; however, IL-1β did not rise until 6 h after challenge. Urantide pretreatment inhibited the degree of TNF-α and IL-1β increase following downregulation of UII post-challenge (all P < 0.05). CONCLUSION: UII plays a role in the pathogenesis and priming of ALF by triggering an inflammatory cascade and driving the early release of cytokines in mice.
- Subjects :
- Lipopolysaccharides
Male
medicine.medical_specialty
Time Factors
Lipopolysaccharide
Urotensins
Interleukin-1beta
Priming (immunology)
Galactosamine
Receptors, G-Protein-Coupled
Pathogenesis
chemistry.chemical_compound
Downregulation and upregulation
Internal medicine
medicine
Animals
Receptor
Mice, Inbred BALB C
business.industry
Tumor Necrosis Factor-alpha
digestive, oral, and skin physiology
Gastroenterology
Interleukin
General Medicine
Liver Failure, Acute
Basic Study
Peptide Fragments
Disease Models, Animal
Endocrinology
chemistry
Liver
Tumor necrosis factor alpha
Inflammation Mediators
business
Urotensin-II
Signal Transduction
Subjects
Details
- ISSN :
- 22192840
- Volume :
- 21
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- World journal of gastroenterology
- Accession number :
- edsair.doi.dedup.....0b09b8f95b04f1cf9c631839b8a5f4e6