Back to Search
Start Over
Determinants of Plasma Docosahexaenoic Acid Levels and Their Relationship to Neurological and Cognitive Functions in PKU Patients: A Double Blind Randomized Supplementation Study
Determinants of Plasma Docosahexaenoic Acid Levels and Their Relationship to Neurological and Cognitive Functions in PKU Patients: A Double Blind Randomized Supplementation Study
- Source :
- Nutrients. 2018 Dec 7;10(12). pii: E1944, Nutrients 10:1944 (2018), Nutrients, Nutrients, Vol 10, Iss 12, p 1944 (2018), UCrea Repositorio Abierto de la Universidad de Cantabria, Universidad de Cantabria (UC), Volume 10, Issue 12
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- Children with phenylketonuria (PKU) follow a protein restricted diet with negligible amounts of docosahexaenoic acid (DHA). Low DHA intakes might explain subtle neurological deficits in PKU. We studied whether a DHA supply modified plasma DHA and neurological and intellectual functioning in PKU. In a double-blind multicentric trial, 109 PKU patients were randomized to DHA doses from 0 to 7 mg/kg&amp<br />day for six months. Before and after supplementation, we determined plasma fatty acid concentrations, latencies of visually evoked potentials, fine and gross motor behavior, and IQ. Fatty acid desaturase genotypes were also determined. DHA supplementation increased plasma glycerophospholipid DHA proportional to dose by 0.4% DHA per 1 mg intake/kg bodyweight. Functional outcomes were not associated with DHA status before and after intervention and remained unchanged by supplementation. Genotypes were associated with plasma arachidonic acid levels and, if considered together with the levels of the precursor alpha-linolenic acid, also with DHA. Functional outcomes and supplementation effects were not significantly associated with genotype. DHA intakes up to 7 mg/kg did not improve neurological functions in PKU children. Nervous tissues may be less prone to low DHA levels after infancy, or higher doses might be required to impact neurological functions. In situations of minimal dietary DHA, endogenous synthesis of DHA from alpha-linolenic acid could relevantly contribute to DHA status.
- Subjects :
- Fatty Acid Desaturases
Male
0301 basic medicine
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Adolescent
Docosahexaenoic Acids
genetic structures
Phenylketonuria
Docosahexaenoic Acid
Cognitive Function
Motor Skills
Neurological Function
Neurological function
lcsh:TX341-641
030209 endocrinology & metabolism
Article
Double blind
03 medical and health sciences
chemistry.chemical_compound
Cognition
0302 clinical medicine
Phenylketonurias
Internal medicine
Humans
Medicine
Restricted diet
Child
chemistry.chemical_classification
030109 nutrition & dietetics
Nutrition and Dietetics
biology
business.industry
nutritional and metabolic diseases
food and beverages
A protein
Fatty acid
Fatty acid desaturase
Endocrinology
chemistry
Docosahexaenoic acid
biology.protein
Female
lipids (amino acids, peptides, and proteins)
Arachidonic acid
business
lcsh:Nutrition. Foods and food supply
Food Science
Subjects
Details
- ISSN :
- 20726643
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....0b0e92c1a16e3d624780d845272215c5
- Full Text :
- https://doi.org/10.3390/nu10121944