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αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus
- Source :
- Mucosal Immunology, Mucosal Immunology, Nature Pub. Group, 2020, ⟨10.1038/s41385-020-0276-8⟩, Mucosal Immunology, 2021, ⟨10.1038/s41385-020-0276-8⟩, Mucosal Immunology, 2020, ⟨10.1038/s41385-020-0276-8⟩
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- International audience; Secretory intestinal IgA can protect from re-infection with rotavirus (RV), but very little is known about the mechanisms that induce IgA production during intestinal virus infections. Classical dendritic cells (cDCs) in the intestine can facilitate both T cell-dependent and -independent secretory IgA. Here, we show that BATF3-dependent cDC1, but not cDC2, are critical for the optimal induction of RV-specific IgA responses in the mesenteric lymph nodes. This depends on the selective expression of the TGF beta-activating integrin alpha v beta 8 by cDC1. In contrast, alpha v beta 8 on cDC1 is dispensible for steady state immune homeostasis. Given that cDC2 are crucial in driving IgA during steady state but are dispensable for RV-specific IgA responses, we propose that the capacity of DC subsets to induce intestinal IgA responses reflects the context, as opposed to an intrinsic property of individual DC subsets.
- Subjects :
- Rotavirus
0301 basic medicine
Integrins
HOMEOSTASIS
[SDV]Life Sciences [q-bio]
Immunology
Integrin
Context (language use)
Antibodies, Viral
medicine.disease_cause
[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity
Rotavirus Infections
Virus
ACTIVATION
03 medical and health sciences
0302 clinical medicine
Antibody Specificity
INFECTION
TGF beta signaling pathway
medicine
Immunology and Allergy
Mesenteric lymph nodes
TGF-BETA-1
REGULATORY T-CELLS
ComputingMilieux_MISCELLANEOUS
TGF beta 1
biology
GROWTH-FACTOR-BETA
INDUCTION
TGF-BETA
Dendritic Cells
Immunoglobulin A
3. Good health
Basic-Leucine Zipper Transcription Factors
030104 developmental biology
medicine.anatomical_structure
[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
B-CELLS
Host-Pathogen Interactions
Immunoglobulin A, Secretory
biology.protein
Cytokines
[SDV.IMM]Life Sciences [q-bio]/Immunology
Homeostasis
030215 immunology
Subjects
Details
- ISSN :
- 19330219 and 19353456
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Mucosal Immunology
- Accession number :
- edsair.doi.dedup.....0b1ee3356c089daea15daecb26a2cccc