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The roles of metastasis-related proteins in the development of giant cell tumor of bone, osteosarcoma and Ewing’s sarcoma
- Source :
- Technology and Health Care
- Publication Year :
- 2021
- Publisher :
- IOS Press, 2021.
-
Abstract
- BACKGROUND: Giant cell tumor of bone (GC), osteosarcoma (OS) and Ewing’s sarcoma (ES) are three different types of bone cancer with common and specific pathology features. OBJECTIVE: The purpose of the study was to examine the relationship and differences of the three bone tumors using clinical samples. METHODS: Through screening the profiles of clinical samples from GC, OS and ES patients using a humanoncology array, we found 26, 25 and 15 tumorigenesis factors significantly increased in GS, OS and ES tissues compared to normal individuals. eNOS, endostatin, HIF-1α, IL-6, CCL2/MCP-1, CCL8/MCP-2, CCL7/MCP-3, Tie and VEGF directly or indirectly involve in the metastasis Therefore, expression levels of the 6 factors were further determined by Western blot. RESULTS: The results showed levels of MCP1, MCP2, MCP3 or IL-6 in the GS, OS and ES significantly increased, and the expression levels of angiogenesis and anti-angiogenesis factors containing eNOS, endostatin, HIF-1α, Tie or VEGF were enhanced. CONCLUSIONS: Our results suggest that eNOS, endostatin, HIF-1α, IL-6, CCL2/MCP-1, CCL8/MCP-2, CCL7/MCP-3, Tie and VEGF may play important roles in tumorigenesis, reveal the expression differences of tumor-associated cytokines and angiogenesis related factors, and provide clinical evidence for studying the mechanisms on the metastasis in GC, OS and ES.
- Subjects :
- Angiogenesis
Blotting, Western
Biomedical Engineering
Biophysics
Bone Neoplasms
Health Informatics
Bioengineering
Sarcoma, Ewing
Biology
Metastasis
Biomaterials
03 medical and health sciences
0302 clinical medicine
medicine
Humans
metastasis
030304 developmental biology
Giant Cell Tumor of Bone
Osteosarcoma
0303 health sciences
Bone cancer
Ewing's sarcoma
medicine.disease
030220 oncology & carcinogenesis
Cancer research
Sarcoma
Ewing’s sarcoma
Endostatin
Research Article
Information Systems
Giant-cell tumor of bone
Subjects
Details
- ISSN :
- 18787401 and 09287329
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Technology and Health Care
- Accession number :
- edsair.doi.dedup.....0b292da08c4367b8fd718507e7df6cce
- Full Text :
- https://doi.org/10.3233/thc-218010