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Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegans
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020), Nature Communications
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group, 2020.
-
Abstract
- Olfactory and metabolic dysfunctions are intertwined phenomena associated with obesity and neurodegenerative diseases; yet how mechanistically olfaction regulates metabolic homeostasis remains unclear. Specificity of olfactory perception integrates diverse environmental odors and olfactory neurons expressing different receptors. Here, we report that specific but not all olfactory neurons actively regulate fat metabolism without affecting eating behaviors in Caenorhabditis elegans, and identified specific odors that reduce fat mobilization via inhibiting these neurons. Optogenetic activation or inhibition of the responsible olfactory neural circuit promotes the loss or gain of fat storage, respectively. Furthermore, we discovered that FLP-1 neuropeptide released from this olfactory neural circuit signals through peripheral NPR-4/neuropeptide receptor, SGK-1/serum- and glucocorticoid-inducible kinase, and specific isoforms of DAF-16/FOXO transcription factor to regulate fat storage. Our work reveals molecular mechanisms underlying olfactory regulation of fat metabolism, and suggests the association between olfactory perception specificity of each individual and his/her susceptibility to the development of obesity.<br />Olfaction is a key sensory modality with high diversity and olfactory defects has been associated with metabolic and neurodegenerative disorders. Here, the authors discovered that specific olfactory inputs actively regulate lipid metabolism in a dynamic and reversible manner.
- Subjects :
- Receptors, Neuropeptide
0301 basic medicine
Olfactory system
Science
General Physics and Astronomy
Neuropeptide
Olfaction
Protein Serine-Threonine Kinases
Biology
Optogenetics
Article
General Biochemistry, Genetics and Molecular Biology
Animals, Genetically Modified
03 medical and health sciences
0302 clinical medicine
Developmental biology
Genetics
Animals
Humans
Obesity
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Receptor
lcsh:Science
Transcription factor
Neurons
Multidisciplinary
Neuropeptides
Forkhead Transcription Factors
Lipid metabolism
Feeding Behavior
General Chemistry
Lipid Metabolism
Olfactory Perception
biology.organism_classification
Neurosecretory Systems
Butanones
Disease Models, Animal
Metabolism
030104 developmental biology
Odorants
lcsh:Q
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....0b8c6d4f14f83c5e2ee51ae641ccddf6