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Systematic Review and Meta-analysis: Mental Health in Children With Neurogenetic Disorders Associated With Intellectual Disability
- Source :
- J Am Acad Child Adolesc Psychiatry
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Objective The behavioral phenotype of neurogenetic disorders associated with intellectual disability often includes psychiatric comorbidity. The objectives of this systematic review and meta-analysis were to systematically review the prevalence of psychiatric disorders and symptoms in children and adolescents with these disorders and compare phenotypic signatures between syndromes. Method MEDLINE and PsycINFO databases were searched for articles from study inception to December 2018. Eligible articles were peer reviewed, were published in English, and reported prevalence data for psychiatric disorders and symptoms in children and adolescents aged 4 to 21 years using a formal psychiatric assessment or a standardized assessment of mental health symptoms. Pooled prevalence was determined using a random-effects meta-analysis in studies with sufficient data. Prevalence estimates were compared with general population data using a test of binomial proportions. Results Of 2,301 studies identified for review, 39 articles were included in the final pool, which provided data on 4,039 children and adolescents. Ten syndromes were represented, and five were predominant: Down syndrome, 22q11.2 deletion syndrome, fragile X syndrome, Williams syndrome, and Prader-Willi syndrome. The Child Behavior Checklist was the most commonly used assessment tool for psychiatric symptoms. The pooled prevalence with total scores above the clinical threshold was lowest for Down syndrome (32% [95% confidence interval, 19%-44%]) and highest for Prader-Willi syndrome (74% [95% CI, 65%-82%]) with each syndrome associated with significantly higher prevalence than in the general population. Parallel trends were observed for the internalizing and externalizing domains and social subscale scores. Conclusion Differential vulnerability for psychiatric phenotype expression across the disorders was observed. Syndromes with higher levels of social ability or competence appear to offer relative protection against developing psychopathology. This preliminary finding merits further exploration.
- Subjects :
- Adult
Down syndrome
medicine.medical_specialty
Adolescent
Population
Comorbidity
Article
Young Adult
Intellectual Disability
Intellectual disability
Prevalence
Developmental and Educational Psychology
medicine
Humans
0501 psychology and cognitive sciences
Child
Psychiatry
education
Child Behavior Checklist
education.field_of_study
business.industry
Mental Disorders
Psychiatric assessment
05 social sciences
medicine.disease
Fragile X syndrome
Psychiatry and Mental health
Mental Health
Child, Preschool
Meta-analysis
business
Prader-Willi Syndrome
050104 developmental & child psychology
Psychopathology
Subjects
Details
- ISSN :
- 08908567
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Journal of the American Academy of Child & Adolescent Psychiatry
- Accession number :
- edsair.doi.dedup.....0bb30fb7700d3badd069e87265720232
- Full Text :
- https://doi.org/10.1016/j.jaac.2020.01.006