Back to Search
Start Over
Polymorphisms in HTLV-1 Tax-responsive elements in HTLV-1-associated myelopathy/tropical spastic paraparesis patients are associated with reduced proviral load but not with disease progression
- Source :
- Journal of General Virology. 102
- Publication Year :
- 2021
- Publisher :
- Microbiology Society, 2021.
-
Abstract
- Human T-lymphotropic virus type 1 (HTLV-1) provirus expression is mainly directed by Tax-responsive elements (TRE) within the long terminal repeats (LTR). Mutations in TRE can reduce provirus expression and since a high proviral load (PVL) is a risk factor for the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), we evaluated polymorphisms in the 5′ LTR and the association with PVL and disease progression. HTLV-1 LTR and tax sequences derived from asymptomatic carriers (AC) and HAM/TSP patients followed in a longitudinal study were analysed according to PVL and clinical severity. Individuals infected with HTLV-1 presenting the canonical TRE, considering strain ATK-1 as the consensus, displayed sustained higher PVL. By contrast, an LTR A125G mutation in TRE was associated with slightly reduced PVL only in HAM/TSP patients, although it did not influence the speed of disease progression. Moreover, this polymorphism was frequent in Latin American strains of the HTLV-1 Cosmopolitan Transcontinental subtype. Therefore, polymorphisms in the 5′ TRE of HTLV-1 may represent one of the factors influencing PVL in HAM/TSP patients, especially in the Latin American population. Indeed, higher PVL in the peripheral blood has been associated with an increased inflammatory activity in the spinal cord and to a poorer prognosis in HAM/TSP. However, this event was not associated with TRE polymorphisms.
- Subjects :
- Male
viruses
Population
Biology
Myelopathy
Proviruses
immune system diseases
Polymorphism (computer science)
Virology
Tropical spastic paraparesis
medicine
Humans
Longitudinal Studies
Risk factor
education
Phylogeny
Aged
Human T-lymphotropic virus 1
education.field_of_study
Polymorphism, Genetic
Terminal Repeat Sequences
virus diseases
Gene Products, tax
Middle Aged
Viral Load
Provirus
medicine.disease
Paraparesis, Tropical Spastic
Long terminal repeat
Asymptomatic Diseases
Carrier State
Mutation
Disease Progression
Female
Asymptomatic carrier
Subjects
Details
- ISSN :
- 14652099 and 00221317
- Volume :
- 102
- Database :
- OpenAIRE
- Journal :
- Journal of General Virology
- Accession number :
- edsair.doi.dedup.....0bc433c7ccef7203ca0cde5cf5c0901a