Studies on Experimental Infection of Weanling Mice with Reoviruses

SummaryA mild to severe respiratory infection was established in mice with reoviruses. In certain animals, the virus was detectable in the respiratory tissues although no evidence of illness was observed. In other animals, respiratory illness was evident early, became overt terminating with the death of the animals. Fluorescent antibody techniques both direct and indirect, correlated with other methods of virus detection. The FA-red cell technique proved to be a rapid, sensitive and highly specific method of reovirus detection and would seem to be applicable for detection of other hemagglutinating viruses.