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Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress in Caenorhabditis elegans
- Source :
- Proceedings of the National Academy of Sciences. 112:15378-15383
- Publication Year :
- 2015
- Publisher :
- Proceedings of the National Academy of Sciences, 2015.
-
Abstract
- Animals in nature are continually challenged by periods of feast and famine as resources inevitably fluctuate, and must allocate somatic reserves for reproduction to abate evolutionary pressures. We identify an age-dependent lipid homeostasis pathway in Caenorhabditis elegans that regulates the mobilization of lipids from the soma to the germline, which supports fecundity but at the cost of survival in nutrient-poor and oxidative stress environments. This trade-off is responsive to the levels of dietary carbohydrates and organismal oleic acid and is coupled to activation of the cytoprotective transcription factor SKN-1 in both laboratory-derived and natural isolates of C. elegans. The homeostatic balance of lipid stores between the somatic and germ cells is mediated by arachidonic acid (omega-6) and eicosapentaenoic acid (omega-3) precursors of eicosanoid signaling molecules. Our results describe a mechanism for resource reallocation within intact animals that influences reproductive fitness at the cost of somatic resilience.
- Subjects :
- Aging
Cell signaling
Somatic cell
Biology
medicine.disease_cause
Germline
chemistry.chemical_compound
Fatty Acids, Omega-6
Fatty Acids, Omega-3
medicine
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Genetics
Multidisciplinary
Reproduction
Vitellogenesis
Biological Sciences
biology.organism_classification
Survival Analysis
Eicosapentaenoic acid
Oxidative Stress
Germ Cells
chemistry
Eicosanoid
Food
Arachidonic acid
Oxidative stress
Oleic Acid
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 112
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....0bcf61aadea0902a8025fc50fd7e4f94