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The Role of Group 3 Innate Lymphoid Cells in Lung Infection and Immunity
- Source :
- Frontiers in Cellular and Infection Microbiology, Vol 11 (2021), Frontiers in Cellular and Infection Microbiology
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- The lung is constantly exposed to environmental particulates such as aeroallergens, pollutants, or microorganisms and is protected by a poised immune response. Innate lymphoid cells (ILCs) are a population of immune cells found in a variety of tissue sites, particularly barrier surfaces such as the lung and the intestine. ILCs play a crucial role in the innate immune system, and they are involved in the maintenance of mucosal homeostasis, inflammation regulation, tissue remodeling, and pathogen clearance. In recent years, group 3 innate lymphoid cells (ILC3s) have emerged as key mediators of mucosal protection and repair during infection, mainly through IL-17 and IL-22 production. Although research on ILC3s has become focused on the intestinal immunity, the biology and function of pulmonary ILC3s in the pathogenesis of respiratory infections and in the development of chronic pulmonary inflammatory diseases remain elusive. In this review, we will mainly discuss how pulmonary ILC3s act on protection against pathogen challenge and pulmonary inflammation, as well as the underlying mechanisms.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Immunology
Population
lcsh:QR1-502
Inflammation
Review
airway inflammation
Microbiology
lcsh:Microbiology
interleukin-17
Interleukin 22
03 medical and health sciences
Cellular and Infection Microbiology
0302 clinical medicine
Immune system
Immunity
Humans
Medicine
Lymphocytes
Group 3 innate lymphoid cells
education
Lung
innate immunity
education.field_of_study
Innate immune system
business.industry
interleukin-22
Innate lymphoid cell
lung infections
Pneumonia
Immunity, Innate
cytokines
030104 developmental biology
Infectious Diseases
medicine.anatomical_structure
medicine.symptom
business
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 22352988
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in Cellular and Infection Microbiology
- Accession number :
- edsair.doi.dedup.....0bde7279143b85c48f53e5d10cabfe9d