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The effect on treatment response of fibromyalgic symptoms in early rheumatoid arthritis patients: results from the ESPOIR cohort

Authors :
Jingbo Niu
Nathalie Rincheval
Bernard Combe
Josefina Durán
David T. Felson
Cécile Gaujoux-Viala
Clinical Epidemiology Research and Training Unit ( BOSTON - Clin Epid Research )
Boston University School
Rheumatology Department ( Rheum Dep - SANTIAGO )
Pontificia Universidad Catolica del Chile
Département de Rhumatologie[Montpellier]
Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Lapeyronie
Institut de Génétique Moléculaire de Montpellier ( IGMM )
Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS )
Department of rheumatology
University of Nimes
Arthritis Research UK Epidemiology Unit ( MANCHESTER - Arthritis Research )
University of Manchester [Manchester]
Centre d'Investigation Clinique INSERM 1412 ( CIC 1412 - BREST )
Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest )
CHRU Brest - Service de Rhumatologie ( CHU - BREST - Rhumato )
Lymphocyte B et Auto-immunité ( LBAI )
Université de Brest ( UBO ) -Institut National de la Santé et de la Recherche Médicale ( INSERM )
Clinical Epidemiology Research and Training Unit (BOSTON - Clin Epid Research)
Boston University School of Medicine (BUSM)
Boston University [Boston] (BU)-Boston University [Boston] (BU)
Rheumatology Department (Rheum Dep - SANTIAGO)
Pontificia Universidad Católica de Chile (UC)
Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie
Institut de Génétique Moléculaire de Montpellier (IGMM)
Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)
Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP)
Université Montpellier 1 (UM1)-Université de Montpellier (UM)
Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
Arthritis Research UK Epidemiology Unit (MANCHESTER - Arthritis Research)
Centre d'Investigation Clinique (CIC - Brest)
Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)
CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato)
Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)
Lymphocyte B et Auto-immunité (LBAI)
Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM)
Service de rhumatologie [CHU Pitié Salpêtrière] (GRC-08 EEMOIS)
Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Boston University [Boston] (BU)
Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM)
Université de Brest (UBO)
CIC Brest
Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Cavale Blanche
Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)
Source :
Rheumatology, Rheumatology, Oxford University Press (OUP), 2015, pp.2166-70, Rheumatology, Oxford University Press (OUP), 2015, pp.2166-70. ⟨10.1093/rheumatology/kev254⟩, Rheumatology, Oxford University Press (OUP), 2017, 56 (7), pp.1244-1244. ⟨10.1093/rheumatology/kew472⟩
Publication Year :
2017
Publisher :
Oxford University Press (OUP), 2017.

Abstract

International audience; OBJECTIVE:To evaluate whether patients with RA who belong to the spectrum of fibromyalgic RA (FRA) have an impaired response to treatment measured by traditional activity scores.METHODS:Patients from the ESPOIR cohort were analysed. This prospective cohort included 813 patients with early arthritis not initially receiving DMARDs. Among the 697 patients who met RA classification criteria, we studied two groups, one with and the other without FRA. The following endpoints were compared at 6, 12 and 18 months using a mixed linear regression model: 28-joint DAS (DAS28), Simple Disease Activity Index (SDAI), Clinical Disease Activity Index (CDAI) and HAQ. In addition, attainment of low disease activity (LDA; DAS28

Subjects

Subjects :
Male
rheumatoid arthritis
MESH: Remission Induction
MESH: Antirheumatic Agents
MESH : Fibromyalgia
[SDV]Life Sciences [q-bio]
early rheumatoid arthritis
MESH : Aged
Arthritis
Severity of Illness Index
DMARDs
Arthritis, Rheumatoid
Cohort Studies
fibromyalgic RA
0302 clinical medicine
Fibromyalgia
MESH : Female
Pharmacology (medical)
030212 general & internal medicine
Prospective cohort study
skin and connective tissue diseases
MESH: Cohort Studies
ComputingMilieux_MISCELLANEOUS
MESH: Treatment Outcome
MESH: Aged
MESH: Arthritis, Rheumatoid
MESH: Middle Aged
Remission Induction
MESH: Follow-Up Studies
Middle Aged
Clinical Science
MESH : Adult
Corrigenda
MESH : Antirheumatic Agents
Treatment Outcome
[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
MESH: Young Adult
Antirheumatic Agents
Rheumatoid arthritis
Cohort
Female
fibromyalgia
MESH : Severity of Illness Index
Adult
musculoskeletal diseases
medicine.medical_specialty
Adolescent
MESH : Male
MESH : Young Adult
MESH : Cohort Studies
MESH : Treatment Outcome
[ SDV.MHEP.RSOA ] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
Young Adult
outcome measures
03 medical and health sciences
Rheumatology
Internal medicine
MESH: Severity of Illness Index
disease activity scores
MESH : Adolescent
[ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology
medicine
Humans
MESH : Middle Aged
Aged
MESH: Adolescent
030203 arthritis & rheumatology
therapy
MESH : Remission Induction
MESH: Fibromyalgia
MESH: Humans
DASS
[ SDV ] Life Sciences [q-bio]
Surrogate endpoint
business.industry
MESH : Humans
MESH: Adult
MESH : Follow-Up Studies
medicine.disease
Crohn's Disease Activity Index
MESH: Male
MESH : Arthritis, Rheumatoid
Physical therapy
business
treat to target
MESH: Female
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Follow-Up Studies

Details

ISSN :
14620332, 14620324, and 14602172
Volume :
56
Database :
OpenAIRE
Journal :
Rheumatology
Accession number :
edsair.doi.dedup.....0bf276ce7abfd219f562e2b5793f8822
Full Text :
https://doi.org/10.1093/rheumatology/kew472