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Contribution of central amiloride-sensitive transport systems to the development of hypertension in spontaneously hypertensive rats
- Source :
- Brain Research. 906:164-169
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- This study was conducted to examine if central amiloride-sensitive transport systems are involved in the development and/or maintenance of hypertension in spontaneously hypertensive rats (SHR). Either amiloride (75 microg/60 microl/day) or artificial cerebrospinal fluid (aCSF, 60 microl/day) was infused centrally (i.c.v.) for 4 weeks to development (4-5-weeks-old) and maintenance (10-12-weeks-old) phases of hypertension in SHR. In development phase, amiloride i.c.v. (n=14) blunted the elevation of blood pressure (BP) compared to aCSF i.c.v. (n=9) (amiloride vs. aCSF; after 3 weeks of i.c.v., 146+/-3 vs. 166+/-5 mmHg, P
- Subjects :
- Male
medicine.medical_specialty
Sympathetic Nervous System
Ganglionic Blockers
Blood Pressure
Hexamethonium
Rats, Inbred WKY
Amiloride
Norepinephrine (medication)
Norepinephrine
chemistry.chemical_compound
Rats, Inbred SHR
Internal medicine
Animals
Medicine
Diuretics
Molecular Biology
business.industry
Angiotensin II
General Neuroscience
Body Weight
Sodium
Brain
Water-Electrolyte Balance
Rats
Autonomic nervous system
Blood pressure
Endocrinology
chemistry
Hypertension
Catecholamine
Neurology (clinical)
Carrier Proteins
business
Artificial cerebrospinal fluid
Developmental Biology
medicine.drug
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 906
- Database :
- OpenAIRE
- Journal :
- Brain Research
- Accession number :
- edsair.doi.dedup.....0c15c021954820033bfce3bda7b888af