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mRNA Expression of SLC5A5 and SLC2A Family Genes in Papillary Thyroid Cancer: An Analysis of The Cancer Genome Atlas
- Source :
- Yonsei Medical Journal
- Publication Year :
- 2018
- Publisher :
- Yonsei University College of Medicine, 2018.
-
Abstract
- Purpose The present study investigated the dynamics and prognostic role of messenger RNA (mRNA) expression responsible for ¹⁸F-fluorodeoxyglucose (FDG) uptake in FDG positron emission tomography (PET) and radioactive iodine (¹³¹I) uptake in whole-body radioactive iodine scans (WBS) in papillary thyroid cancer (PTC) patients. Materials and methods The primary and processed data were downloaded from the Genomic Data Commons Data Portal. Expression data for sodium/iodide symporter (solute carrier family 5 member 5, SLC5A5), hexokinase (HK1-3), glucose-6-phosphate dehydrogenase (G6PD), and glucose transporter (solute carrier family 2, SLC2A1-4) mRNA were collected. Results Expression of SLC5A5 mRNA were negatively correlated with SLC2A1 mRNA and positively correlated with SLC2A4 mRNA. In PTC with BRAF mutations, expressions of SLC2A1, SLC2A3, HK2, and HK3 mRNA were higher than those in PTC without BRAF mutations. Expression of SLC5A5, SLC2A4, HK1, and G6PD mRNA was lower in PTC without BRAF mutation. PTCs with higher expression of SLC5A5 mRNA had more favorable disease-free survival, but no association with overall survival. Conclusion Expression of SLC5A5 mRNA was negatively correlated with SLC2A1 mRNA. This finding provides a molecular basis for the management of PTC with negative WBS using ¹⁸F-FDG PET scans. In addition, higher expression of SLC5A5 mRNA was associated with less PTC recurrence, but not with deaths.
- Subjects :
- Adult
Male
Proto-Oncogene Proteins B-raf
endocrine system diseases
030209 endocrinology & metabolism
Biology
Thyroid cancer
fluorodeoxyglucose
Disease-Free Survival
Papillary thyroid cancer
SLC5A5
Iodine Radioisotopes
03 medical and health sciences
Endocrinology & Metabolism
0302 clinical medicine
positron emission tomograph
Fluorodeoxyglucose F18
medicine
Humans
RNA, Messenger
Thyroid Neoplasms
Gene
Aged
Fluorodeoxyglucose
Messenger RNA
Glucose Transporter Type 1
Symporters
Glucose transporter
General Medicine
Middle Aged
medicine.disease
Carcinoma, Papillary
Solute carrier family
Thyroid Cancer, Papillary
030220 oncology & carcinogenesis
Positron-Emission Tomography
Symporter
Mutation
Cancer research
Original Article
Female
Radiopharmaceuticals
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 19762437 and 05135796
- Volume :
- 59
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Yonsei Medical Journal
- Accession number :
- edsair.doi.dedup.....0c1f6649c98a4c3087599b3c9aea08fe