Back to Search
Start Over
Hyperbaric Oxygen Therapy as a Sole Agent Is Not Immunosuppressant in a Highly Immunogenic Mouse Model
- Source :
- Bone Marrow Research, Vol 2011 (2011), Bone Marrow Research
- Publication Year :
- 2011
-
Abstract
- Background. Hyperbaric oxygen (HBO) therapy, which is used for many conditions, may also have immunosuppressive effects and could be used for prevention or treatment of graft-versus-host disease (GvHD). If HBO is immunosuppressant, then we hypothesize that HBO therapy will delay the T-cell mediated skin graft rejection. Methods. C57/BL6 black-coated (H2B) mice received skin graft from CBA (H2D) white-coated mice. Mice were treated with either 19 session of 240 kpa oxygen or 29 session of 300 kpa oxygen, for 90 minutes. Mice were housed either 4 per cage or separately, to prevent friction and mechanical factors that may affect graft survival. Skin grafts were assessed daily. Results. There was no difference in length of graft survival between mice that received either regimens of HBO therapy and mice that did not receive HBO therapy. Conclusions. HBO therapy, as a sole agent, did not delay skin graft rejection in a highly immunogenic mouse model.
- Subjects :
- medicine.medical_specialty
Graft rejection
Article Subject
lcsh:RC633-647.5
business.industry
Biolääketieteet - Biomedicine
Immunology
lcsh:Diseases of the blood and blood-forming organs
Cell Biology
Hematology
Surgery
Hyperbaric oxygen
surgical procedures, operative
medicine
Graft survival
business
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Bone Marrow Research, Vol 2011 (2011), Bone Marrow Research
- Accession number :
- edsair.doi.dedup.....0c28f1de998b314a096a7b7b921620fc