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Serum gamma-glutamyl transferase, a marker of alcohol intake, is associated with telomere length and cardiometabolic risk in young adulthood
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021), Scientific Reports, 11(1):12407. Nature Publishing Group, SCIENTIFIC REPORTS, Scientific Reports, Bijnens, E M, Derom, C, Thiery, E, Martens, D S, Loos, R J F, Weyers, S & Nawrot, T S 2021, ' Serum gamma-glutamyl transferase, a marker of alcohol intake, is associated with telomere length and cardiometabolic risk in young adulthood ', Scientific Reports, vol. 11, no. 1, 12407 . https://doi.org/10.1038/s41598-021-91987-6
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Studies based on self-reported alcohol consumption and telomere length show inconsistent results. Therefore, we studied the association between gamma-glutamyl transferase (GGT), a widely used biomarker of alcohol intake, and telomere length. The possible health relevance in young adulthood was explored by investigating cardiometabolic risk factors. Mixed modelling was performed to examine GGT and alcohol consumption in association with telomere length in buccal cells of 211 adults between 18 and 30 years old of the East Flanders Prospective Twin Survey. In addition, we investigated the association between GGT and cardiometabolic risk factors; waist circumference, systolic blood pressure, fasting glucose, HDL cholesterol, and triglycerides. Although we did not observe an association between self-reported alcohol consumption and telomere length, our results show that a doubling in serum GGT is associated with 7.80% (95% CI - 13.9 to - 1.2%; p=0.02) shorter buccal telomeres, independently from sex, chronological age, educational level, zygosity and chorionicity, waist-to-hip ratio and smoking. The association between GGT was significant for all five cardiometabolic risk factors, while adjusting for age. We show that GGT, a widely used biomarker of alcohol consumption, is associated with telomere length and with risk factors of cardiometabolic syndrome, despite the young age of this study population. This investigation is supported by the EU research council “project ENVIRONAGE” (ERC-2012-StG 310890), and the Flemish Scientifc Fund (FWO, G073315N). Dr. Bijnens holds a fellow-ship from the Marguerite-Marie Delacroix foundation. Dr. Martens is a postdoctoral fellow of the FWO (12X9620N). Since its start, the East Flanders Prospective Twin Survey has been partly supported by grants from the Fund of Scientifc Research Flanders and Twins, a non-proft Association for Scientifc Research in Multiple Births (Belgium).
- Subjects :
- Male
Molecular biology
Buccal swab
Physiology
chemistry.chemical_compound
0302 clinical medicine
Medicine and Health Sciences
Medicine
Young adult
OXIDATIVE STRESS
POPULATION
METABOLIC SYNDROME
Metabolic Syndrome
0303 health sciences
Multidisciplinary
gamma-Glutamyltransferase
Telomere
3. Good health
Multidisciplinary Sciences
030220 oncology & carcinogenesis
Science & Technology - Other Topics
Biomarker (medicine)
Population study
Female
GLUTAMYLTRANSFERASE
Adult
Waist
Adolescent
Alcohol Drinking
Science
Article
03 medical and health sciences
Young Adult
DIETARY
Humans
EXPOSURE
METAANALYSIS
030304 developmental biology
Science & Technology
business.industry
Cholesterol
CONSUMPTION
Zygosity
LIFE
Blood pressure
chemistry
Risk factors
CIGARETTE-SMOKING
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....0c493fc2734fe18b7fd56445e6af7d92