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An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the 'Legs at odd angles' (Loa) mutation
- Source :
- Gene. 283(1-2)
- Publication Year :
- 2002
-
Abstract
- A variety of loci with interesting patterns of regulation such as imprinted expression, and critical functions such as involvement in tumour necrosis factor pathways, map to a distal portion of mouse chromosome 12. This region also contains disease related loci including the 'Legs at odd angles' mutation (Loa) that we are pursuing in a positional cloning project. To further define the region and prepare for comparative sequencing projects, we have produced genetic, radiation hybrid, physical and transcript maps of the region, with probes providing anchors between the maps. We show a summary of 95 markers and 91 genomic clones that has enabled us to identify 18 transcripts including new genes and candidates for Loa which will help in future studies of gene context and regulation.
- Subjects :
- Genetics
Chromosomes, Human, Pair 14
Radiation Hybrid Mapping
Positional cloning
Transcription, Genetic
Physical Chromosome Mapping
Chromosome Mapping
Locus (genetics)
General Medicine
Biology
Synteny
Chromosomes
Contig Mapping
Genomic Imprinting
Mice
Gene Order
Animals
Humans
Radiation hybrid mapping
Genomic imprinting
Gene
Chromosome 12
Subjects
Details
- ISSN :
- 03781119
- Volume :
- 283
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- Gene
- Accession number :
- edsair.doi.dedup.....0c4e6f04b38af1bfb9bf8ad5c474da96