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Vascular endothelial injury in severe fever with thrombocytopenia syndrome caused by the novel bunyavirus
- Source :
- Virology. 520:11-20
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Severe fever with thrombocytopenia syndrome virus (SFTSV) infection typically causes acute fever, thrombocytopenia and leucopenia, presenting with a high case fatality rate. The pathogenesis of SFTSV infection, however, is not well described. It was hypothesized that endothelial dysfunction might play part in the disease process. In current study, we retrospectively analyzed the clinical manifestations among a large group of confirmed SFTS cases and found evidence of plasma leakage and vascular endothelial injury. Then we established a SFTSV infection cell model and determined the infectivity and stimulation of SFTSV on vascular endothelial cells in vitro. The hyperpermeability of endothelial cells directly induced by SFTSV was confirmed by electrical resistance and dextran diffusion assay. The virus induced alterations of cell junctions and cytoskeleton was also revealed. It's suggested that vascular endothelial cell injury and barrier function damage were induced after SFTSV infection, which is a vital but neglected pathogenesis of SFTS.
- Subjects :
- Phlebovirus
0301 basic medicine
Fever
Endothelium
Inflammation
Biology
Bunyaviridae Infections
Virus
Capillary Permeability
Cohort Studies
Pathogenesis
03 medical and health sciences
Virology
medicine
Humans
Endothelial dysfunction
Retrospective Studies
medicine.disease
Thrombocytopenia
Endothelial stem cell
Severe fever with thrombocytopenia syndrome
030104 developmental biology
medicine.anatomical_structure
Immunology
Cytokines
Endothelium, Vascular
medicine.symptom
Severe fever with thrombocytopenia syndrome virus
Subjects
Details
- ISSN :
- 00426822
- Volume :
- 520
- Database :
- OpenAIRE
- Journal :
- Virology
- Accession number :
- edsair.doi.dedup.....0c5875e904ea90cd50f3db0041851d80