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Effectiveness of Tocolytic Agents on Prevention of Preterm Delivery, Neonatal Morbidity, and Mortality
- Source :
- Obstetrical & Gynecological Survey. 71:243-252
- Publication Year :
- 2016
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2016.
-
Abstract
- Preterm delivery presents the main cause of neonatal morbidity and mortality worldwide. The rate of preterm delivery is 12% to 13% in the United States, of which 29% concerns preterm deliveries before 34 weeks of gestation. Basic parameter of prevention strategy is implementation of tocolytic therapy in cases of threatened preterm labor. Several therapeutic approaches have been proposed, among which betamimetic agonists, calcium channel blockers, magnesium sulfate, oxytocin receptor blockers, nitrates, and prostaglandin inhibitors, whereas new alternatives such as usage of thiocolchicoside have also been reported. This article is one among few that aims to review the comparative effectiveness of various tocolytic agents regarding prevention of preterm delivery, impact on perinatal morbidity and mortality, neonatal health status, and maternal complications. Main conclusions of recent randomized control trials and meta-analyses are summarized to assess about which agents consensus already exists on their effectiveness, which agents should be further studied to achieve conclusions, as well as those that are rather unlikely to have significant tocolytic impact or any other benefit on neonatal outcome.
- Subjects :
- Comparative Effectiveness Research
Pediatrics
medicine.medical_specialty
Tocolytic agent
Consensus
Comparative effectiveness research
law.invention
03 medical and health sciences
Obstetric Labor, Premature
0302 clinical medicine
Randomized controlled trial
Pregnancy
law
Infant Mortality
Humans
Medicine
Intensive care medicine
030219 obstetrics & reproductive medicine
business.industry
Infant, Newborn
Infant
Obstetrics and Gynecology
General Medicine
medicine.disease
United States
Infant mortality
Tocolytic Agents
Treatment Outcome
Premature birth
Tocolytic
Prostaglandin inhibitor
Premature Birth
Female
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00297828
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Obstetrical & Gynecological Survey
- Accession number :
- edsair.doi.dedup.....0c640d9d60d03ed3c2cf93f1b6e5579f