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Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study
- Source :
- The Lancet Diabetes & Endocrinology. 3:526-534
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Background Indian Asians, who make up a quarter of the world's population, are at high risk of developing type 2 diabetes. We investigated whether DNA methylation is associated with future type 2 diabetes incidence in Indian Asians and whether differences in methylation patterns between Indian Asians and Europeans are associated with, and could be used to predict, differences in the magnitude of risk of developing type 2 diabetes. Methods We did a nested case-control study of DNA methylation in Indian Asians and Europeans with incident type 2 diabetes who were identified from the 8-year follow-up of 25 372 participants in the London Life Sciences Prospective Population (LOLIPOP) study. Patients were recruited between May 1, 2002, and Sept 12, 2008. We did epigenome-wide association analysis using samples from Indian Asians with incident type 2 diabetes and age-matched and sex-matched Indian Asian controls, followed by replication testing of top-ranking signals in Europeans. For both discovery and replication, DNA methylation was measured in the baseline blood sample, which was collected before the onset of type 2 diabetes. Epigenome-wide significance was set at p
- Subjects :
- Male
STRESS
Endocrinology, Diabetes and Metabolism
PROTEIN
Type 2 diabetes
GLUCOSE
Epigenesis, Genetic
MELLITUS
0302 clinical medicine
Endocrinology
Risk Factors
Prospective Studies
media_common
2. Zero hunger
INSULIN-RESISTANCE
0303 health sciences
education.field_of_study
Incidence (epidemiology)
Middle Aged
3. Good health
CARBOHYDRATE RESPONSE ELEMENT
OBESITY
Female
Life Sciences & Biomedicine
EXPRESSION
Asian Continental Ancestry Group
Genetic Markers
SUSCEPTIBILITY LOCI
European Continental Ancestry Group
Population
030209 endocrinology & metabolism
Article
White People
Endocrinology & Metabolism
03 medical and health sciences
INFLAMMATION
Asian People
Diabetes mellitus
Internal Medicine
medicine
Humans
media_common.cataloged_instance
European union
education
030304 developmental biology
Science & Technology
business.industry
Case-control study
DNA Methylation
medicine.disease
Obesity
Diabetes Mellitus, Type 2
Case-Control Studies
Nested case-control study
business
Genome-Wide Association Study
Demography
Subjects
Details
- ISSN :
- 22138587
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- The Lancet Diabetes & Endocrinology
- Accession number :
- edsair.doi.dedup.....0c8fe15eaa109d21e7207b6416a49e76