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Improvement of endocardial and vascular endothelial function on myocardial performance by captopril treatment in postinfarct rat hearts
- Source :
- Circulation
- Publication Year :
- 1999
-
Abstract
- Background —Endocardial (EE) and myocardial capillary vascular endothelial (myocap VE) cells have been shown to modulate the contractile characteristics of myocardium in a calcium-dependent manner. We evaluated the endothelial-myocardial interaction in the rat postinfarction myocardial infarction (MI) model and the effects of captopril. Methods and Results —Wistar rats were divided into 4 groups treated for 4 weeks: (1) control; (2) infarcted controls (left anterior coronary artery ligation); (3) infarcted+captopril 2 g/L in drinking water; and (4) infarct+captopril+triton intracoronary injection. Coronary VE function was evaluated by infusion of serotonin in Langendorff preparations (n=31), and the myocardial contractile characteristics were investigated by use of isolated papillary muscles (n=44). Cardiac mRNA for endothelial constitutive nitric oxide synthase (ecNOS) was measured, and its cellular location was evaluated by immunohistochemistry. Serotonin-induced increase in coronary flow was decreased in infarct controls compared with controls (4.6% versus 53.4%, P 2 ). Cardiac ecNOS mRNA decreased in the control infarct group but remained normal in the infarct+captopril group. Conclusions —Chronic postinfarction endothelium-induced coronary vasodilatation is impaired, and both EE and myocap VE dysfunction contribute to myocardial depression. Captopril use prevents these abnormalities and the reduction of cardiac ecNOS mRNA.
- Subjects :
- medicine.medical_specialty
Serotonin
Captopril
Heart disease
Endothelium
Nitric Oxide Synthase Type III
Myocardial Infarction
Angiotensin-Converting Enzyme Inhibitors
Contractility
Physiology (medical)
Internal medicine
medicine
Animals
cardiovascular diseases
Myocardial infarction
RNA, Messenger
Rats, Wistar
biology
business.industry
Myocardium
Angiotensin-converting enzyme
Heart
medicine.disease
Coronary Vessels
Immunohistochemistry
Myocardial Contraction
Capillaries
Rats
Endocrinology
medicine.anatomical_structure
Heart failure
cardiovascular system
biology.protein
Cardiology
Endothelium, Vascular
Nitric Oxide Synthase
Cardiology and Cardiovascular Medicine
business
medicine.drug
Endocardium
Subjects
Details
- ISSN :
- 15244539 and 00097322
- Volume :
- 100
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Circulation
- Accession number :
- edsair.doi.dedup.....0c9518405f1d3089e4741e5761a18dce