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Diabetes-related end-stage renal disease in Austria 1965-2013
- Source :
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 30(11)
- Publication Year :
- 2014
-
Abstract
- BACKGROUND Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) in Austria, accounting for a high burden of morbidity and mortality. In this nationwide study, we aimed to evaluate the incidence and fate of patients with DKD-ESRD over time. METHODS Data (collected annually) from the Austrian Dialysis- and Transplant Registry were analysed for the development of ESRD due to DKD from 1965 to 2013. RESULTS Over 48 years, 8322 and 22 975 patients with ESRD due to diabetes and non-diabetes, respectively, entered dialysis. While DKD-ESRD-patients were not dialysed until 1974, in 1975 seven type 1- and one type 2-diabetics started dialysis (1.06 per million population-PMP). In the mid-eighties, DKD-ESRD-patients increasingly were accepted for dialysis (1986: 14.53 PMP, 1996: 31.16 PMP). After a peak incidence of 415 diabetic ESRD-patients in 2006 (50.19 PMP), numbers decreased continuously thereafter (2013: 299 patients, 35.73 PMP). Mean age at start of dialysis increased over time and was lower in type 1- and higher in type 2- compared with non-diabetic patients. Five-year-survival-probability in two diabetic ESRD-cohorts, starting in 2007/08 and 10 years earlier was calculated. Five-year-survival was 28% in 1997/98 and 37.5% in 2007/08. Adjusted relative risk reduction was 33% (HR 0.67, CI 95% 0.57-0.78; P < 0.001). CONCLUSION Despite a growing prevalence of diabetes, the incidence of diabetic ESRD has decreased after 2006. Five-year-survival-probability has improved over 10 years. Multifactorial therapeutic interventions may have resulted in this improvement.
- Subjects :
- Relative risk reduction
Adult
Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Disease
End stage renal disease
Diabetic nephropathy
Renal Dialysis
Internal medicine
Diabetes mellitus
medicine
Prevalence
Humans
Diabetic Nephropathies
Registries
Intensive care medicine
Dialysis
Aged
Transplantation
business.industry
Incidence (epidemiology)
Incidence
Middle Aged
medicine.disease
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Nephrology
Austria
Kidney Failure, Chronic
Female
Hemodialysis
business
Subjects
Details
- ISSN :
- 14602385
- Volume :
- 30
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
- Accession number :
- edsair.doi.dedup.....0ca1149f402e503d5decf3afc91f4d3f