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Risk of hospital admission for liver injury in users of NSAIDs and nonoverdose paracetamol: Preliminary results from the EPIHAM study

Risk of hospital admission for liver injury in users of NSAIDs and nonoverdose paracetamol: Preliminary results from the EPIHAM study

Authors :
Anaïs Chartier
Nicholas Moore
A. Grolleau
Régis Lassalle
Sinem Ezgi Gulmez
Ulku Sur Unal
Grolleau, Adeline
CIC Bordeaux
Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM)
Bordeaux PharmacoEpi, Inserm CIC1401, Université de Bordeaux
Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Tekirdağ Çerkezköy Tepe Emlak Family Medicine Centre
This study was supported by an unconditional public joint grant from Direction Générale de la Santé (DGS), from Mission recherche de la Direction de la recherche, des études, de l’évaluation et des statistiques (MiRe-DREES) of Caisse Nationale d’Assurance Maladie des Travailleurs Salariés (CNAMTS), Régime Social Indépendants (RSI) and Caisse Nationale de Solidarité́ pour l’Autonomie (CNSA), as part of the general call for projects by IReSP (Appel à Projets, Institut de Recherche en Santé Publique).
Cette recherche a bénéficié de l’aide conjointe de la Direction Générale de la Santé (DGS), de la Mission recherche de la Direction de la recherche, des études, de l’évaluation et des statistiques (MiRe-DREES) de la Caisse Nationale d’Assurance Maladie des Travailleurs Salariés (CNAMTS), du Régime Social des Indépendants (RSI) et de la Caisse Nationale de Solidarité pour l’Autonomie (CNSA), dans le cadre de l’appel à projets général lancé par l’IReSP (Institut de Recherche en Santé Publique).
Source :
Pharmacoepidemiology and Drug Safety, Pharmacoepidemiology and Drug Safety, Wiley, 2018, 27 (11), pp.1174-1181. ⟨10.1002/pds.4640⟩
Publication Year :
2018

Abstract

This is the peer reviewed version of the following article: "Risk of hospital admission for liver injury in users of NSAIDs and nonoverdose paracetamol: Preliminary results from the EPIHAM study", which has been published in final form at https://onlinelibrary.wiley.com/doi/full/10.1002/pds.4640.This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.; International audience; Purpose: The SALT study found similar per-user risks of acute liver failure (ALF) leading to transplantation (ALFT) between NSAIDs and a three-fold higher risk in non-overdose paracetamol (NOP) users. The objective of EPIHAM was to identify the risks of hospital admission for acute liver injury (ALI) associated with NSAIDs and NOP. Methods: Case-population study included in the 1/97 sample of the French population claims database. ALI was identified from hospital discharge summaries, from 2009 to 2013. Exposure for cases was dispensation of NSAID or NOP resulting in exposure within 30 days before admission. Population exposure was number of patients using the drugs over the study timeframe and total number of DDD dispensed. Results: Of 63 cases of ALI, 13 had been exposed to NSAIDs and 24 to NOP. Events per million DDD [95%CI] ranged from 0.46 [0.09-1.34] (ketoprofen) to 1.43 [0.04-7.97] (diclofenac combinations), 0.43 [0.23-0.73] all NSAIDs combined, 0.58 [0.37-0.86] for NOP. There was no association with average duration of treatment. Per patient risk ranged from 19.5 [5.31-49.9] (ibuprofen) per million users to 37.2 [19.8-63.6] all NSAIDs combined, 58.0 [37.2-86.3] for NOP. There was a linear relationship between average treatment duration and per-user risk (R2=0.51, p

Details

Language :
English
ISSN :
10538569 and 10991557
Database :
OpenAIRE
Journal :
Pharmacoepidemiology and Drug Safety, Pharmacoepidemiology and Drug Safety, Wiley, 2018, 27 (11), pp.1174-1181. ⟨10.1002/pds.4640⟩
Accession number :
edsair.doi.dedup.....0cd73e829c2d40b0d8cd2a97a782a9c4
Full Text :
https://doi.org/10.1002/pds.4640⟩